Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 2241250..2242169 | Replicon | chromosome |
| Accession | NZ_CP096846 | ||
| Organism | Mycobacterium tuberculosis variant bovis strain Mb2377 | ||
Toxin (Protein)
| Gene name | HigB2 | Uniprot ID | L7N4R2 |
| Locus tag | M1775_RS10500 | Protein ID | WP_003900449.1 |
| Coordinates | 2241564..2242169 (-) | Length | 202 a.a. |
Antitoxin (Protein)
| Gene name | HigA2 | Uniprot ID | L7N5K9 |
| Locus tag | M1775_RS10495 | Protein ID | WP_003410124.1 |
| Coordinates | 2241250..2241555 (-) | Length | 102 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M1775_RS10465 (M1775_10470) | 2236261..2237517 | - | 1257 | WP_003410095.1 | HNH endonuclease signature motif containing protein | - |
| M1775_RS10470 (M1775_10475) | 2237871..2238446 | + | 576 | WP_003410100.1 | hypothetical protein | - |
| M1775_RS10475 (M1775_10480) | 2238443..2239483 | + | 1041 | WP_003410103.1 | ImmA/IrrE family metallo-endopeptidase | - |
| M1775_RS10480 (M1775_10485) | 2239725..2240444 | + | 720 | WP_010950643.1 | DUF433 domain-containing protein | - |
| M1775_RS10485 (M1775_10490) | 2240434..2240850 | + | 417 | WP_003410114.1 | hypothetical protein | - |
| M1775_RS10490 (M1775_10495) | 2240866..2241165 | - | 300 | WP_003410120.1 | hypothetical protein | - |
| M1775_RS10495 (M1775_10500) | 2241250..2241555 | - | 306 | WP_003410124.1 | XRE family transcriptional regulator | Antitoxin |
| M1775_RS10500 (M1775_10505) | 2241564..2242169 | - | 606 | WP_003900449.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| M1775_RS10505 (M1775_10510) | 2242194..2242553 | - | 360 | WP_003410131.1 | hypothetical protein | - |
| M1775_RS10510 (M1775_10515) | 2242713..2243366 | - | 654 | WP_014324107.1 | hypothetical protein | - |
| M1775_RS10515 (M1775_10520) | 2243342..2243578 | - | 237 | WP_003410133.1 | hypothetical protein | - |
| M1775_RS10520 (M1775_10525) | 2243785..2244681 | - | 897 | WP_011799238.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 202 a.a. Molecular weight: 22744.96 Da Isoelectric Point: 7.3073
>T243940 WP_003900449.1 NZ_CP096846:c2242169-2241564 [Mycobacterium tuberculosis variant bovis]
VNVPWENAHGGALYCLIRGDEFSAWHRLLFQRPGCAESVLACRHFLDGSPVARCSYPEEYHPCVISRIALLCDSVGWTAD
VERISAWLNGLDRETYELVFAAIEVLEEEGPALGCPLVDTVRGSRHKNMKELRPGSQGRSEVRILFAFDPARQAIMLAAG
NKAGRWTQWYDEKIKAADEMFAEHLAQFEDTKPKRRKRKKG
VNVPWENAHGGALYCLIRGDEFSAWHRLLFQRPGCAESVLACRHFLDGSPVARCSYPEEYHPCVISRIALLCDSVGWTAD
VERISAWLNGLDRETYELVFAAIEVLEEEGPALGCPLVDTVRGSRHKNMKELRPGSQGRSEVRILFAFDPARQAIMLAAG
NKAGRWTQWYDEKIKAADEMFAEHLAQFEDTKPKRRKRKKG
Download Length: 606 bp
Antitoxin
Download Length: 102 a.a. Molecular weight: 11291.91 Da Isoelectric Point: 10.7482
>AT243940 WP_003410124.1 NZ_CP096846:c2241555-2241250 [Mycobacterium tuberculosis variant bovis]
MAMTLRDMDAVRPVNREAVDRHKARMRDEVRAFRLRELRAAQSLTQVQVAALAHIRQSRVSSIENGDIGSAQVNTLRKYV
SALGGELDITVRLGDETFTLA
MAMTLRDMDAVRPVNREAVDRHKARMRDEVRAFRLRELRAAQSLTQVQVAALAHIRQSRVSSIENGDIGSAQVNTLRKYV
SALGGELDITVRLGDETFTLA
Download Length: 306 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BV20 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U4BV30 |