Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 1102625..1103278 Replicon chromosome
Accession NC_013416
Organism Aggregatibacter actinomycetemcomitans D11S 1

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag D11S_RS05675 Protein ID WP_005578509.1
Coordinates 1103096..1103278 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag D11S_RS05670 Protein ID WP_005545975.1
Coordinates 1102625..1103044 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D11S_RS05640 (D11S_02635) 1098648..1099061 + 414 WP_005539234.1 hydroxyisourate hydrolase -
D11S_RS05645 (D11S_1182) 1099255..1100205 + 951 WP_005545964.1 hypothetical protein -
D11S_RS05650 (D11S_1183) 1100706..1100882 - 177 WP_005545966.1 AlpA family phage regulatory protein -
D11S_RS05655 (D11S_1184) 1101511..1101735 - 225 WP_005545968.1 hypothetical protein -
D11S_RS05660 (D11S_1185) 1101800..1102156 - 357 WP_005545970.1 DUF2513 domain-containing protein -
D11S_RS05665 (D11S_1186) 1102240..1102599 + 360 WP_005545972.1 hypothetical protein -
D11S_RS05670 (D11S_1187) 1102625..1103044 - 420 WP_005545975.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
D11S_RS05675 (D11S_02645) 1103096..1103278 - 183 WP_005578509.1 type II toxin-antitoxin system HicA family toxin Toxin
D11S_RS05680 (D11S_1188) 1103531..1104682 + 1152 WP_005545976.1 type I restriction endonuclease -
D11S_RS05685 (D11S_1190) 1104993..1106231 + 1239 WP_005545980.1 phage antirepressor N-terminal domain-containing protein -
D11S_RS05690 (D11S_1191) 1106231..1106842 + 612 WP_005590093.1 DUF4376 domain-containing protein -
D11S_RS05695 1106839..1107597 - 759 WP_005545985.1 DUF4102 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1099255..1107582 8327


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-63)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6952.13 Da        Isoelectric Point: 10.1091

>T24383 WP_005578509.1 NC_013416:c1103278-1103096 [Aggregatibacter actinomycetemcomitans D11S-1]
MKYSEFLRYLLEQGCKVEATKRGSHRKVTLNECQTVFPYHGSKEIGTGLVHKIKKDLNLK

Download         Length: 183 bp

>T24383 NC_013416:c1103278-1103096 [Aggregatibacter actinomycetemcomitans D11S-1]
ATGAAATACAGTGAATTCTTGCGATACTTGCTTGAGCAAGGCTGCAAAGTCGAAGCAACCAAGCGCGGAAGTCATCGCAA
GGTAACGTTGAATGAGTGCCAAACTGTCTTTCCCTACCATGGTAGTAAAGAAATCGGTACCGGCTTAGTTCACAAAATCA
AAAAAGACTTAAACTTAAAATAA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15871.34 Da        Isoelectric Point: 4.7175

>AT24383 WP_005545975.1 NC_013416:c1103044-1102625 [Aggregatibacter actinomycetemcomitans D11S-1]
MLRYPVEITPDDNGTFLVTCPDIPEMASVGEDIESALLEAEEGLETALEFYFDDKRPIPMPSQPKDGQYTVPLSLLRSLK
VFLLNEMLAQGVRKAEMARRLDVHMPQVDRLLDFRHPSKIDFVEKAFKKLGREINLSVH

Download         Length: 420 bp

>AT24383 NC_013416:c1103044-1102625 [Aggregatibacter actinomycetemcomitans D11S-1]
ATGTTACGCTACCCTGTTGAAATCACCCCGGATGATAACGGTACATTCCTTGTCACTTGCCCCGATATTCCCGAAATGGC
AAGTGTAGGTGAAGATATTGAAAGCGCACTACTTGAAGCGGAAGAAGGTTTAGAAACCGCCCTCGAATTTTATTTTGATG
ATAAACGCCCAATTCCAATGCCAAGCCAGCCAAAAGATGGGCAATATACGGTTCCGCTTTCCTTATTGCGTTCACTAAAA
GTCTTCTTACTCAATGAAATGCTCGCACAAGGTGTGCGAAAAGCTGAAATGGCGCGCCGTCTTGATGTTCACATGCCGCA
AGTCGATCGCTTATTAGATTTTCGCCACCCATCCAAAATTGATTTTGTTGAAAAAGCCTTTAAAAAATTAGGGCGCGAAA
TTAATTTATCGGTTCATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References