Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 1282456..1283109 Replicon chromosome
Accession NZ_CP093910
Organism Aggregatibacter actinomycetemcomitans strain 27R

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag MQG43_RS06535 Protein ID WP_005578509.1
Coordinates 1282927..1283109 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag MQG43_RS06530 Protein ID WP_005545975.1
Coordinates 1282456..1282875 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQG43_RS06500 1278479..1278892 + 414 WP_005539234.1 hydroxyisourate hydrolase -
MQG43_RS06505 1279086..1280036 + 951 WP_005545964.1 hypothetical protein -
MQG43_RS06510 1280537..1280713 - 177 WP_005545966.1 AlpA family phage regulatory protein -
MQG43_RS06515 1281342..1281566 - 225 WP_005545968.1 hypothetical protein -
MQG43_RS06520 1281631..1281987 - 357 WP_005545970.1 DUF2513 domain-containing protein -
MQG43_RS06525 1282071..1282430 + 360 WP_005545972.1 hypothetical protein -
MQG43_RS06530 1282456..1282875 - 420 WP_005545975.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
MQG43_RS06535 1282927..1283109 - 183 WP_005578509.1 type II toxin-antitoxin system HicA family toxin Toxin
MQG43_RS06540 1283362..1284513 + 1152 WP_005545976.1 type I restriction endonuclease -
MQG43_RS06545 1284824..1286062 + 1239 WP_258271155.1 phage antirepressor N-terminal domain-containing protein -
MQG43_RS06550 1286062..1286673 + 612 WP_005590093.1 DUF4376 domain-containing protein -
MQG43_RS06555 1286670..1287428 - 759 WP_005545985.1 DUF4102 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 1278479..1287413 8934


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-63)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6952.13 Da        Isoelectric Point: 10.1091

>T238974 WP_005578509.1 NZ_CP093910:c1283109-1282927 [Aggregatibacter actinomycetemcomitans]
MKYSEFLRYLLEQGCKVEATKRGSHRKVTLNECQTVFPYHGSKEIGTGLVHKIKKDLNLK

Download         Length: 183 bp

>T238974 NZ_LR890554:327183-327551 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15871.34 Da        Isoelectric Point: 4.7175

>AT238974 WP_005545975.1 NZ_CP093910:c1282875-1282456 [Aggregatibacter actinomycetemcomitans]
MLRYPVEITPDDNGTFLVTCPDIPEMASVGEDIESALLEAEEGLETALEFYFDDKRPIPMPSQPKDGQYTVPLSLLRSLK
VFLLNEMLAQGVRKAEMARRLDVHMPQVDRLLDFRHPSKIDFVEKAFKKLGREINLSVH

Download         Length: 420 bp

>AT238974 NZ_LR890554:326965-327186 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References