Detailed information of TA system TA024382

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 1060726..1061372
• Replicon: chromosome
• Accession: NC_013416
• Organism: Aggregatibacter actinomycetemcomitans D11S 1

Toxin (Protein)

• Gene name: higB
• Uniprot ID: X2JQ23
• Locus tag: D11S_RS05450
• Protein ID: WP_005555126.1
• Coordinates: 1060726..1061076 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: D11S_RS05455
• Protein ID: WP_005545913.1
• Coordinates: 1061073..1061372 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D11S_RS05430 (D11S_1139)	1055901..1056146	-	246	WP_005540815.1	YgjV family protein	-
D11S_RS05435 (D11S_1140)	1056340..1057677	-	1338	WP_005545903.1	argininosuccinate synthase	-
D11S_RS05440 (D11S_1141)	1057772..1058599	-	828	WP_005545905.1	hypothetical protein	-
D11S_RS05445 (D11S_1143)	1058956..1060539	+	1584	WP_005545909.1	peptide chain release factor 3	-
D11S_RS05450 (D11S_1144)	1060726..1061076	+	351	WP_005555126.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D11S_RS05455 (D11S_1145)	1061073..1061372	+	300	WP_005545913.1	helix-turn-helix transcriptional regulator	Antitoxin
D11S_RS05460 (D11S_1146)	1061408..1064341	-	2934	WP_005545915.1	bifunctional [glutamate--ammonia ligase]-adenylyl-L-tyrosine phosphorylase/[glutamate--ammonia-ligase] adenylyltransferase	-
D11S_RS05465 (D11S_02625)	1064543..1064770	+	228	WP_005567423.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (32-80)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 13518.64 Da
• Isoelectric Point: 9.9664

>T24382 WP_005555126.1 NC_013416:1060726-1061076 [Aggregatibacter actinomycetemcomitans D11S-1]
MWAVILTERFETWLNQQPIKTQECVLANLVRLEHFGPNLARPYVDSVAGSIHSNMKELRVQHSGRAIRLFFAFDPKRRAI
VLCGGDKGNDKRFYRTMIRIADQELNHYLATMEQTK

Nucleotide

• Length: 351 bp

>T24382 NC_013416:1060726-1061076 [Aggregatibacter actinomycetemcomitans D11S-1]
ATGTGGGCGGTGATTTTAACGGAACGATTTGAAACTTGGTTAAATCAACAGCCGATAAAAACGCAGGAATGTGTTTTGGC
AAACTTGGTACGGTTGGAACATTTTGGTCCGAATTTAGCCCGTCCTTATGTAGATAGCGTAGCAGGGTCAATTCATAGCA
ACATGAAAGAACTACGCGTTCAGCATTCGGGAAGAGCAATTCGACTCTTTTTTGCTTTTGATCCAAAGCGTAGAGCCATT
GTTTTATGTGGTGGAGATAAAGGCAATGACAAGCGGTTTTACCGTACGATGATTAGAATTGCAGATCAAGAATTGAATCA
TTATTTGGCAACCATGGAGCAAACAAAATGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11390.16 Da
• Isoelectric Point: 5.8598

>AT24382 WP_005545913.1 NC_013416:1061073-1061372 [Aggregatibacter actinomycetemcomitans D11S-1]
MKTLQQVIDERSVESRQRIQTMAEDLILETGLQLLREELNISQQQLATILGVTQPAINQLEQRGNEIKLATLKRYIEAMG
GKLRLSVEMPDGHQRFFQI

Nucleotide

• Length: 300 bp

>AT24382 NC_013416:1061073-1061372 [Aggregatibacter actinomycetemcomitans D11S-1]
ATGAAAACATTACAACAAGTTATTGATGAACGTTCGGTAGAAAGCCGCCAACGTATTCAAACCATGGCGGAAGATTTAAT
TCTTGAAACCGGTTTGCAACTGTTGCGAGAAGAATTAAATATATCGCAACAACAATTAGCTACGATTTTAGGTGTAACTC
AACCTGCAATTAATCAACTGGAACAGCGTGGCAATGAAATTAAGCTTGCAACCCTCAAACGTTACATCGAAGCAATGGGC
GGCAAATTACGCCTTAGTGTAGAAATGCCTGATGGACATCAGCGGTTTTTTCAAATTTAA

Structures

Toxin

• AlphaFold DB: X2JQ23