Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 3501838..3502508 | Replicon | chromosome |
| Accession | NZ_CP096843 | ||
| Organism | Mycobacterium tuberculosis variant bovis strain Mb3602 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | M1781_RS16525 | Protein ID | WP_079293460.1 |
| Coordinates | 3501838..3502182 (+) | Length | 115 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | G0THF6 |
| Locus tag | M1781_RS16530 | Protein ID | WP_003899955.1 |
| Coordinates | 3502179..3502508 (+) | Length | 110 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M1781_RS16490 (M1781_16495) | 3496911..3497771 | + | 861 | WP_003416628.1 | alpha/beta hydrolase | - |
| M1781_RS16495 (M1781_16500) | 3497746..3498261 | + | 516 | WP_003899950.1 | nitroreductase family deazaflavin-dependent oxidoreductase | - |
| M1781_RS16500 (M1781_16505) | 3498277..3498488 | + | 212 | Protein_3257 | (R)-hydratase | - |
| M1781_RS16505 (M1781_16510) | 3498501..3498794 | + | 294 | WP_003416635.1 | hypothetical protein | - |
| M1781_RS16510 (M1781_16515) | 3499082..3500371 | + | 1290 | WP_003416640.1 | ATP-binding protein | - |
| M1781_RS16515 (M1781_16520) | 3500718..3501152 | - | 435 | WP_003899952.1 | type II toxin-antitoxin system VapC family toxin | - |
| M1781_RS16520 (M1781_16525) | 3501155..3501607 | - | 453 | WP_003899953.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| M1781_RS16525 (M1781_16530) | 3501838..3502182 | + | 345 | WP_079293460.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| M1781_RS16530 (M1781_16535) | 3502179..3502508 | + | 330 | WP_003899955.1 | XRE family transcriptional regulator | Antitoxin |
| M1781_RS16535 (M1781_16540) | 3503046..3503393 | + | 348 | WP_003899956.1 | DUF2384 domain-containing protein | - |
| M1781_RS16540 (M1781_16545) | 3503390..3504010 | + | 621 | WP_003899957.1 | RES family NAD+ phosphorylase | - |
| M1781_RS16545 (M1781_16550) | 3504170..3505435 | - | 1266 | WP_079293458.1 | hypothetical protein | - |
| M1781_RS16550 (M1781_16555) | 3505603..3505812 | + | 210 | WP_003416778.1 | hypothetical protein | - |
| M1781_RS16555 (M1781_16560) | 3506059..3507093 | - | 1035 | WP_003416786.1 | IS30 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 115 a.a. Molecular weight: 12711.54 Da Isoelectric Point: 5.8432
>T243782 WP_079293460.1 NZ_CP096843:3501838-3502182 [Mycobacterium tuberculosis variant bovis]
MAVILLPQVERWFFALNRDAMASVTGAIDLLEMEGPTLGRPVVDKVNDSTFHNMKELRPAGTSIRILFAFDPARQAILLL
GGDKAGNWKRWYDNNIPIADQRSENWLASERGGG
MAVILLPQVERWFFALNRDAMASVTGAIDLLEMEGPTLGRPVVDKVNDSTFHNMKELRPAGTSIRILFAFDPARQAILLL
GGDKAGNWKRWYDNNIPIADQRSENWLASERGGG
Download Length: 345 bp
>T243782 NZ_OX465025:c239529-239194 [Streptococcus agalactiae]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGTTAAAGGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCGACATCAGGTCAGCACAAAATGGAGCAAATCATTAGTGACATAGAAAAACTCGAGGTTTTCCCTGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGTAAGTACCACAGCACTAGAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGAGGAAGAGAATAGGGTCGTTATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
GAAATTGTTTAAATAG
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGTTAAAGGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCGACATCAGGTCAGCACAAAATGGAGCAAATCATTAGTGACATAGAAAAACTCGAGGTTTTCCCTGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGTAAGTACCACAGCACTAGAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGAGGAAGAGAATAGGGTCGTTATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
GAAATTGTTTAAATAG
Antitoxin
Download Length: 110 a.a. Molecular weight: 11802.46 Da Isoelectric Point: 7.4051
>AT243782 WP_003899955.1 NZ_CP096843:3502179-3502508 [Mycobacterium tuberculosis variant bovis]
MTMARNWRDIRADAVAQGRVDLQRAAVAREEMRDAVLAHRLAEIRKALGHARQADVAALMGVSQARVSKLESGDLSHTEL
GTLQAYVAALGGHLRIVAEFGENTVELTA
MTMARNWRDIRADAVAQGRVDLQRAAVAREEMRDAVLAHRLAEIRKALGHARQADVAALMGVSQARVSKLESGDLSHTEL
GTLQAYVAALGGHLRIVAEFGENTVELTA
Download Length: 330 bp
>AT243782 NZ_OX465025:c239806-239519 [Streptococcus agalactiae]
ATGGTTACAGCAGAAAAAAATAGAGCTGTCACATTCCAAGCTAACAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAGAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTTCAAAATGTCGTTGTCACAAATGAGGTTGACTTATTGA
CGGAAGAGGAGCTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAAGATGTTCGTCAA
GGGAAATTTTATACCTCTGAAGAAGTGAGGTCTGAACTTGGACTATAA
ATGGTTACAGCAGAAAAAAATAGAGCTGTCACATTCCAAGCTAACAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAGAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTTCAAAATGTCGTTGTCACAAATGAGGTTGACTTATTGA
CGGAAGAGGAGCTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAAGATGTTCGTCAA
GGGAAATTTTATACCTCTGAAGAAGTGAGGTCTGAACTTGGACTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|