Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Gp49-HTH_37
Location 2189426..2190294 Replicon chromosome
Accession NZ_CP096843
Organism Mycobacterium tuberculosis variant bovis strain Mb3602

Toxin (Protein)


Gene name higB Uniprot ID P9WJA4
Locus tag M1781_RS10190 Protein ID WP_010886136.1
Coordinates 2189426..2189803 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID G0TLM0
Locus tag M1781_RS10195 Protein ID WP_003409886.1
Coordinates 2189845..2190294 (+) Length 150 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1781_RS10140 (M1781_10150) 2185215..2185667 - 453 WP_010950636.1 lipoprotein -
M1781_RS10145 (M1781_10155) 2185731..2186132 + 402 WP_003409869.1 hypothetical protein -
M1781_RS10150 (M1781_10160) 2186125..2186307 - 183 WP_003409870.1 hypothetical protein -
M1781_RS10155 (M1781_10165) 2186421..2186771 - 351 WP_003409871.1 hypothetical protein -
M1781_RS10160 (M1781_10170) 2186782..2187684 - 903 WP_003409874.1 hypothetical protein -
M1781_RS10165 (M1781_10175) 2187705..2187896 - 192 WP_003409876.1 hypothetical protein -
M1781_RS10170 (M1781_10180) 2187897..2188193 - 297 WP_003409877.1 hypothetical protein -
M1781_RS10175 (M1781_10185) 2188433..2188648 + 216 WP_003409878.1 antitoxin -
M1781_RS10180 (M1781_10190) 2188645..2188950 + 306 WP_079293638.1 type II toxin-antitoxin system VapC family toxin -
M1781_RS10185 (M1781_10195) 2188930..2189451 - 522 WP_165690532.1 hypothetical protein -
M1781_RS10190 (M1781_10200) 2189426..2189803 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB Toxin
M1781_RS10195 (M1781_10205) 2189845..2190294 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
M1781_RS10200 (M1781_10210) 2190291..2190836 + 546 WP_003409891.1 SecB-like chaperone -
M1781_RS10205 (M1781_10215) 2190725..2191339 - 615 WP_003901296.1 hypothetical protein -
M1781_RS10210 (M1781_10220) 2191388..2191684 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin -
M1781_RS10215 (M1781_10225) 2191681..2191932 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin -
M1781_RS10220 (M1781_10230) 2191919..2192413 + 495 WP_003899099.1 hypothetical protein -
M1781_RS10225 (M1781_10235) 2192573..2192980 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
M1781_RS10230 (M1781_10240) 2192984..2193256 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
M1781_RS10235 (M1781_10245) 2193289..2194509 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(27-113)

Antitoxin

Cro/C1-type helix-turn-helix domain

(44-91)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14397.77 Da        Isoelectric Point: 10.8862

>T243759 WP_010886136.1 NZ_CP096843:2189426-2189803 [Mycobacterium tuberculosis variant bovis]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI

Download         Length: 378 bp

>T243759 NZ_OX461103:c1283297-1282521 [Streptococcus agalactiae]
ATGGAATTAGAAGCATTTAGTCAGACAGATTTTGACCTAGCTTTAAAACGGAGTATTCGTTCTCTGACACGAGGAAAAAC
TTTTTCAACTAATCCTCAAGCTATCTTACTCGGTGGACAAAGCGGTGCAGGCAAGACGACCATACACCGGATTAAACAAA
AGGAATTTCAAGGCAATATCATCATTATTGATGGCGATAGCTATCACTCTCTACATCCCAATTATCTTACCCTACAAGAG
AAATATGGCAAAGGTAGCGTCGATTACACCAAAGACTTTGCAGGAAAAATGGTGGAACATCTTGTTGATGAGCTCAGCAA
ACAAGGTTATCATCTGTTAATTGAAGGGACTTTGCGTACCACTCAAGTTCCTCGTCAGACTGCTCAATTATTAGCTTCGA
AAGAATACCAAGTTTCCTTAGCTGTTATTGGTACCAAAACAGAACTTTCTTATCTCAGCACCTTGATTCGTTATGAAGAA
CTTTATACCATTGATCCCAATCAGGCCAGAGCAACACCTAAAGAACTTCACGATGGGATTGTAGAGCATTTAGTTGATAA
TTTACGAGAGCTAGAAGACGCCTGTCTCTTTGACCAAATTAAAATTTACCAAAGAGACAGGCTTTGTGTTTATGATTCTG
AAACTGATGAAGGCTCAGCAGCAGATGTCCTACAAGAATGTCTCTTCGGAAAATGGAGCAAGGTCGAGGAGGAGATGTTA
AAGGTGGGACAGGAACGGTTGAGGGAGATGGTTAAGAGGAGCGGCAACGATGTCTAG

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 16760.16 Da        Isoelectric Point: 8.0771

>AT243759 WP_003409886.1 NZ_CP096843:2189845-2190294 [Mycobacterium tuberculosis variant bovis]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA

Download         Length: 450 bp

>AT243759 NZ_OX461103:c1283773-1283297 [Streptococcus agalactiae]
ATGATTGGAGAGAATATCAAATCACTACGTCGGACACACGATTTAACACAGCCAGAATTTGCGAAAATGGTTGGGATTTC
ACGCAATAGCCTGAGTCGTTATGAAAATGGGACTAGTACAGTTTCAACAGAACTCATCGACCGTATTTGTCAAAAATTTA
ACGTTTCTTATGTCGATATTGTAGGGGAGGATAAGATGCTAACACCTGTTGAAGATTACCAACTGACTTTAAAAGTAGAA
GTGATCAAAGAACGTGGAGCAGCCATTTTATCGAAGCTCTATCGATATCAAGATAGTCAAGATATTGCTTTTGATGATGA
ATCAAATCCTTGGATTTTGATGAGTGATGATTTGGCTGAATTAATCAATACAAAGATTTACCTTGTCGATACCTTCGATG
AAATTGAGCGTTACAATGGGTACTTAGACGGTATTGAGCGTATGCTAGAGCTTGCCAGTCATCAGGTGGTAGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AWK
PDB 7NBU

Antitoxin

Source ID Structure
PDB 5MTW
AlphaFold DB G0TLM0

References