Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/Gp49-HTH_37 |
| Location | 2190732..2191600 | Replicon | chromosome |
| Accession | NZ_CP096841 | ||
| Organism | Mycobacterium tuberculosis variant bovis strain Mb0820 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | P9WJA4 |
| Locus tag | M1774_RS10185 | Protein ID | WP_010886136.1 |
| Coordinates | 2190732..2191109 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | G0TLM0 |
| Locus tag | M1774_RS10190 | Protein ID | WP_003409886.1 |
| Coordinates | 2191151..2191600 (+) | Length | 150 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M1774_RS10135 (M1774_10145) | 2186522..2186974 | - | 453 | WP_010950636.1 | lipoprotein | - |
| M1774_RS10140 (M1774_10150) | 2187038..2187439 | + | 402 | WP_003409869.1 | hypothetical protein | - |
| M1774_RS10145 (M1774_10155) | 2187432..2187614 | - | 183 | WP_003409870.1 | hypothetical protein | - |
| M1774_RS10150 (M1774_10160) | 2187728..2188078 | - | 351 | WP_003409871.1 | hypothetical protein | - |
| M1774_RS10155 (M1774_10165) | 2188089..2188990 | - | 902 | Protein_2006 | hypothetical protein | - |
| M1774_RS10160 (M1774_10170) | 2189011..2189202 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| M1774_RS10165 (M1774_10175) | 2189203..2189499 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| M1774_RS10170 (M1774_10180) | 2189739..2189954 | + | 216 | WP_003409878.1 | antitoxin | - |
| M1774_RS10175 (M1774_10185) | 2189951..2190262 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| M1774_RS10180 (M1774_10190) | 2190236..2190757 | - | 522 | WP_010950637.1 | hypothetical protein | - |
| M1774_RS10185 (M1774_10195) | 2190732..2191109 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | Toxin |
| M1774_RS10190 (M1774_10200) | 2191151..2191600 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | Antitoxin |
| M1774_RS10195 (M1774_10205) | 2191597..2192142 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| M1774_RS10200 (M1774_10210) | 2192031..2192645 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| M1774_RS10205 (M1774_10215) | 2192694..2192990 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| M1774_RS10210 (M1774_10220) | 2192987..2193238 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| M1774_RS10215 (M1774_10225) | 2193225..2193719 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| M1774_RS10220 (M1774_10230) | 2193879..2194286 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| M1774_RS10225 (M1774_10235) | 2194290..2194562 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| M1774_RS10230 (M1774_10240) | 2194595..2195815 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14397.77 Da Isoelectric Point: 10.8862
>T243642 WP_010886136.1 NZ_CP096841:2190732-2191109 [Mycobacterium tuberculosis variant bovis]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
Download Length: 378 bp
>T243642 NZ_OX419575:2091774-2091866 [Bacillus subtilis]
ATGTCAACATTCCAGGCATTAATGCTAATGCTTGCAATCGGGTCGTTTATAATCGCCCTATTGACGTATATAGAAAAAAT
AGACCTCCCTTGA
ATGTCAACATTCCAGGCATTAATGCTAATGCTTGCAATCGGGTCGTTTATAATCGCCCTATTGACGTATATAGAAAAAAT
AGACCTCCCTTGA
Antitoxin
Download Length: 150 a.a. Molecular weight: 16760.16 Da Isoelectric Point: 8.0771
>AT243642 WP_003409886.1 NZ_CP096841:2191151-2191600 [Mycobacterium tuberculosis variant bovis]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
Download Length: 450 bp
>AT243642 NZ_OX419575:c2092020-2091847 [Bacillus subtilis]
TTACAATACATTACAGTGCATTTCTTTAATGAGAAATGCATAAAATAAAAAAGACCGAGGTGCTACCAACACCCCGGCTC
TGTACAAAAAGTTGCCCATCAAAGGGCTTGCTCGATGTGGTTCTAGGTAGGCCTATCCCTTCAGGTTCTGAGGCTCAAGG
GAGGTCTATTTTTT
TTACAATACATTACAGTGCATTTCTTTAATGAGAAATGCATAAAATAAAAAAGACCGAGGTGCTACCAACACCCCGGCTC
TGTACAAAAAGTTGCCCATCAAAGGGCTTGCTCGATGTGGTTCTAGGTAGGCCTATCCCTTCAGGTTCTGAGGCTCAAGG
GAGGTCTATTTTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|