Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/Gp49-HTH_37 |
| Location | 2197272..2198140 | Replicon | chromosome |
| Accession | NZ_CP096839 | ||
| Organism | Mycobacterium tuberculosis variant bovis strain Mb2487 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | P9WJA4 |
| Locus tag | M1779_RS10255 | Protein ID | WP_010886136.1 |
| Coordinates | 2197272..2197649 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | G0TLM0 |
| Locus tag | M1779_RS10260 | Protein ID | WP_003409886.1 |
| Coordinates | 2197691..2198140 (+) | Length | 150 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M1779_RS10205 (M1779_10210) | 2193061..2193513 | - | 453 | WP_010950636.1 | lipoprotein | - |
| M1779_RS10210 (M1779_10215) | 2193577..2193978 | + | 402 | WP_003409869.1 | hypothetical protein | - |
| M1779_RS10215 (M1779_10220) | 2193971..2194153 | - | 183 | WP_003409870.1 | hypothetical protein | - |
| M1779_RS10220 (M1779_10225) | 2194267..2194617 | - | 351 | WP_003409871.1 | hypothetical protein | - |
| M1779_RS10225 (M1779_10230) | 2194628..2195530 | - | 903 | WP_003409874.1 | hypothetical protein | - |
| M1779_RS10230 (M1779_10235) | 2195551..2195742 | - | 192 | WP_003409876.1 | hypothetical protein | - |
| M1779_RS10235 (M1779_10240) | 2195743..2196039 | - | 297 | WP_003409877.1 | hypothetical protein | - |
| M1779_RS10240 (M1779_10245) | 2196279..2196494 | + | 216 | WP_003409878.1 | antitoxin | - |
| M1779_RS10245 (M1779_10250) | 2196491..2196802 | + | 312 | WP_003409881.1 | type II toxin-antitoxin system VapC family toxin | - |
| M1779_RS10250 (M1779_10255) | 2196776..2197297 | - | 522 | WP_010950637.1 | hypothetical protein | - |
| M1779_RS10255 (M1779_10260) | 2197272..2197649 | + | 378 | WP_010886136.1 | type II toxin-antitoxin system toxin HigB | Toxin |
| M1779_RS10260 (M1779_10265) | 2197691..2198140 | + | 450 | WP_003409886.1 | type II toxin-antitoxin system antitoxin HigA | Antitoxin |
| M1779_RS10265 (M1779_10270) | 2198137..2198682 | + | 546 | WP_003409891.1 | SecB-like chaperone | - |
| M1779_RS10270 (M1779_10275) | 2198571..2199185 | - | 615 | WP_003901296.1 | hypothetical protein | - |
| M1779_RS10275 (M1779_10280) | 2199234..2199530 | - | 297 | WP_003409896.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| M1779_RS10280 (M1779_10285) | 2199527..2199778 | - | 252 | WP_003409899.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| M1779_RS10285 (M1779_10290) | 2199765..2200259 | + | 495 | WP_003899099.1 | hypothetical protein | - |
| M1779_RS10290 (M1779_10295) | 2200419..2200826 | - | 408 | WP_003409913.1 | type II toxin-antitoxin system VapC family toxin | - |
| M1779_RS10295 (M1779_10300) | 2200830..2201102 | - | 273 | WP_003899100.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
| M1779_RS10300 (M1779_10305) | 2201135..2202355 | - | 1221 | WP_003409919.1 | TetR family transcriptional regulator Mce3R | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14397.77 Da Isoelectric Point: 10.8862
>T243525 WP_010886136.1 NZ_CP096839:2197272-2197649 [Mycobacterium tuberculosis variant bovis]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI
Download Length: 378 bp
>T243525 NZ_OX359175:866258-866668 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA
Antitoxin
Download Length: 150 a.a. Molecular weight: 16760.16 Da Isoelectric Point: 8.0771
>AT243525 WP_003409886.1 NZ_CP096839:2197691-2198140 [Mycobacterium tuberculosis variant bovis]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA
Download Length: 450 bp
>AT243525 NZ_OX359175:866011-866277 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|