Detailed information of TA system TA243489

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): DinJ-YafQ (relBE)/YafQ-RelB
• Location: 3775836..3776338
• Replicon: chromosome
• Accession: NZ_CP096837
• Organism: Escherichia coli strain PS10-3

Toxin (Protein)

• Gene name: yafQ
• Uniprot ID: -
• Locus tag: MYF74_RS17820
• Protein ID: WP_112044409.1
• Coordinates: 3776099..3776338 (+)
• Length: 80 a.a.

Antitoxin (Protein)

• Gene name: dinJ
• Uniprot ID: Q32JN2
• Locus tag: MYF74_RS17815
• Protein ID: WP_000729709.1
• Coordinates: 3775836..3776096 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MYF74_RS17795 (3771519)	3771519..3772304	-	786	WP_163450530.1	putative lateral flagellar export/assembly protein LafU	-
MYF74_RS17800 (3772276)	3772276..3773988	+	1713	Protein_3500	flagellar biosynthesis protein FlhA	-
MYF74_RS17805 (3774204)	3774204..3774701	-	498	WP_112044410.1	transposase	-
MYF74_RS17810 (3774877)	3774877..3775626	-	750	WP_000056850.1	C40 family peptidase	-
MYF74_RS17815 (3775836)	3775836..3776096	+	261	WP_000729709.1	type II toxin-antitoxin system antitoxin DinJ	Antitoxin
MYF74_RS17820 (3776099)	3776099..3776338	+	240	WP_112044409.1	type II toxin-antitoxin system YafQ family toxin	Toxin
MYF74_RS17825 (3776533)	3776533..3777273	+	741	WP_001225690.1	peptidoglycan meso-diaminopimelic acid protein amidase	-
MYF74_RS17830 (3777244)	3777244..3778011	-	768	WP_000333380.1	class II glutamine amidotransferase	-
MYF74_RS17835 (3778217)	3778217..3778795	-	579	WP_000284050.1	D-sedoheptulose 7-phosphate isomerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-77)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-84)

Sequences

Toxin

Protein

• Length: 80 a.a.
• Molecular weight: 9398.06 Da
• Isoelectric Point: 9.8890

>T243489 WP_112044409.1 NZ_CP096837:3776099-3776338 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNILPLPAVYKDHPLQGSWKGYRDAHVEPDWLLIYKLTDKLL

Nucleotide

• Length: 240 bp

>T243489 NZ_OX352940:532584-532850 [Streptococcus suis]
ATGAAGACCTGTTATAAACTCGTACCGACCAGTCGTTTTATTAAACAGTTGAAAAAGTTGGACAAATTTACCCAAAAACA
GATTACCAACTACCTGTCCAGTCATGTGACTGACAACCCTAGACAATACGGAAAAGCCTTAACTGCCAATCGTTCTGGCC
AATGGCGCTACCGTATCGGCAATTACAGGGTTATCGTCAGCATTGAAGATGACAAATTGATTGTGACAGCCCTTGAAGTC
GGGCATCGGAAAGAAATATATAAATAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9333.73 Da
• Isoelectric Point: 5.8129

>AT243489 WP_000729709.1 NZ_CP096837:3775836-3776096 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVGVHKAKDADDL
FDKLGI

Nucleotide

• Length: 261 bp

>AT243489 NZ_OX352940:532349-532600 [Streptococcus suis]
ATGGCAGCTATTACATTGAAAGTTTCTGAGCAGGACAAGCTCTTTATGCAGGCTATGGCAAAGTTTGAAGGTGTCAGTTT
GTCAGAACTCATTCGGACTAAAACCCTTGAAGCTCTCGAAGATGAATATGATGCCCGTGTGGCAGATATCGCTCTGTCTG
AATACGAGGCAGACTTGGCGAAAGGCATTGAGCCGATTAGCTGGGAGGAAATGTTGGAAGAGTTGGGGTTGACGGATGAA
GACCTGTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A829FY17