Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 639229..640028 Replicon chromosome
Accession NZ_CP096837
Organism Escherichia coli strain PS10-3

Toxin (Protein)


Gene name yhaV Uniprot ID -
Locus tag MYF74_RS03055 Protein ID WP_062882798.1
Coordinates 639229..639693 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID -
Locus tag MYF74_RS03060 Protein ID WP_021568806.1
Coordinates 639693..640028 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MYF74_RS03025 (634230) 634230..634664 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
MYF74_RS03030 (634682) 634682..635560 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
MYF74_RS03035 (635550) 635550..636329 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
MYF74_RS03040 (636340) 636340..636813 - 474 WP_241952400.1 PTS N-acetylgalactosamine transporter subunit IIB -
MYF74_RS03045 (636836) 636836..638116 - 1281 WP_248748161.1 tagatose-bisphosphate aldolase subunit KbaZ -
MYF74_RS03050 (638365) 638365..639174 + 810 WP_096982344.1 aga operon transcriptional regulator AgaR -
MYF74_RS03055 (639229) 639229..639693 - 465 WP_062882798.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
MYF74_RS03060 (639693) 639693..640028 - 336 WP_021568806.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
MYF74_RS03065 (640177) 640177..641748 - 1572 WP_097435326.1 galactarate dehydratase -
MYF74_RS03070 (642123) 642123..643457 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
MYF74_RS03075 (643473) 643473..644243 + 771 WP_053273578.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17852.20 Da        Isoelectric Point: 9.2151

>T243473 WP_062882798.1 NZ_CP096837:c639693-639229 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFDAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEETH

Download         Length: 465 bp

>T243473 NZ_OX352806:570318-570500 [Streptococcus suis]
ATGCCTATGACACAAAAAGAAATGGTTAAACTTCTTACCGCCAACGGTTGGACAAAGACCAAAGGCGGTAAAGGGTCACA
CGTTAAACTTGAAAAAGCAGGCGAGCGACCTATAACCATTCCCCACGGTGAAATTAACAAATACACCGAAAGGGGTATCA
AAAAGCAAGCAGGGCTGTTATAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12357.96 Da        Isoelectric Point: 5.1296

>AT243473 WP_021568806.1 NZ_CP096837:c640028-639693 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGNEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT243473 NZ_OX352806:570540-570992 [Streptococcus suis]
ATGCTTGTCACTTATCCAGCTTTATTTTATTATGACGATACAGACGGAGCTAGCGCCCCTTATTTTGTCACTTTCCCAGA
CTTTGAACATTCAGCAACTCAAGGCGAAGATATGGCAAACGCTATGGCAATGGCTAGTGATTGGTTAGGTATTCATCTAG
CTGATTATATTGAGAATGGGCGAGATATTCCCATTCCTACCCCTATTAACACCTTATCTTTAGCAGATAATAACCCTTTC
CATGATGATGAGGATATAGAGCTTATCTATGACCCTAGTAAGTCTTTTATTTCTATGGTTATGGTTGATGTTGCCGAGTA
TTTAGGTAGCCAAGAACCTATAAAGAAGACTCTAACTATCCCACGTTGGGCGGATACTTTAGGGCGTGAGCTAGGATTGA
ATTTCTCACAGACCTTAACAGACGCTATTGCAGATAAGAAAATTCATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References