Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 4606816..4607318 | Replicon | chromosome |
| Accession | NZ_CP096834 | ||
| Organism | Escherichia coli strain PM4-5 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | MYF75_RS23850 | Protein ID | WP_000767829.1 |
| Coordinates | 4607064..4607318 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | MYF75_RS23845 | Protein ID | WP_001259255.1 |
| Coordinates | 4606816..4607067 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MYF75_RS23820 (4601993) | 4601993..4603060 | - | 1068 | WP_001548749.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
| MYF75_RS23825 (4603060) | 4603060..4604130 | - | 1071 | WP_113441097.1 | histidinol-phosphate transaminase | - |
| MYF75_RS23830 (4604127) | 4604127..4605431 | - | 1305 | WP_113441096.1 | histidinol dehydrogenase | - |
| MYF75_RS23835 (4605437) | 4605437..4606336 | - | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
| MYF75_RS23840 (4606482) | 4606482..4606532 | - | 51 | WP_001364200.1 | his operon leader peptide | - |
| MYF75_RS23845 (4606816) | 4606816..4607067 | + | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| MYF75_RS23850 (4607064) | 4607064..4607318 | + | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| MYF75_RS23855 (4607401) | 4607401..4608225 | + | 825 | WP_000754737.1 | SDR family oxidoreductase | - |
| MYF75_RS23860 (4608271) | 4608271..4609200 | + | 930 | WP_000803366.1 | LysR substrate-binding domain-containing protein | - |
| MYF75_RS23865 (4609415) | 4609415..4609477 | + | 63 | WP_010723108.1 | membrane protein YoeI | - |
| MYF75_RS23870 (4609467) | 4609467..4610825 | + | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| MYF75_RS23875 (4611004) | 4611004..4612062 | + | 1059 | WP_000492305.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| MYF75_RS23880 (4612076) | 4612076..4612303 | + | 228 | WP_000985273.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T243464 WP_000767829.1 NZ_CP096834:4607064-4607318 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T243464 NZ_OX352324:c1257084-1256713 [Pseudomonas sp. MM221]
ATGGATGCATTAAAACGAATCAGGGCACTTTACTGGGTCGGCAGCAGCAAGAAGGACCTTCAGGCACTTCCTGAGGATGT
ACAGGACATCTTCGGCTTTGCGCTGCACCTGGCGCAGGAAGGCGGCAAACATCAGCAAACCAAGTGCCTCAAGGGATTCT
CAGGTGCGGGTGTACTGGAAGTCATGGAGGACCACAACCGGAACACCTACCGAGCTGTCTACACCGTCAGTTTTGGCTCG
GCAGTTTATGTCCTGCATTGCTTCCAGAAGAAGTCCACCTCTGGCATCAAGACTTCCAGTCACGACATCGCCTTGATCAG
GTCTCGCCTGAAGCTGGCGGAGGCACACTCAAGAGGAGATACAAATGACTGA
ATGGATGCATTAAAACGAATCAGGGCACTTTACTGGGTCGGCAGCAGCAAGAAGGACCTTCAGGCACTTCCTGAGGATGT
ACAGGACATCTTCGGCTTTGCGCTGCACCTGGCGCAGGAAGGCGGCAAACATCAGCAAACCAAGTGCCTCAAGGGATTCT
CAGGTGCGGGTGTACTGGAAGTCATGGAGGACCACAACCGGAACACCTACCGAGCTGTCTACACCGTCAGTTTTGGCTCG
GCAGTTTATGTCCTGCATTGCTTCCAGAAGAAGTCCACCTCTGGCATCAAGACTTCCAGTCACGACATCGCCTTGATCAG
GTCTCGCCTGAAGCTGGCGGAGGCACACTCAAGAGGAGATACAAATGACTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT243464 WP_001259255.1 NZ_CP096834:4606816-4607067 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT243464 NZ_OX352324:c1256720-1256400 [Pseudomonas sp. MM221]
ATGACTGAGATCGAAACAGGCAGCGGGAACGTTTATGCCGACCTCAACAGTGCCGACGCCAATGAAATGCTGGTAAAGGC
ACAGCTTGCCAGCAAGATCTGCAGCATCATCAAGGCTCGTCATCTCACTCAGGTGCAGGCCGCAGCGGTACTTGGGTTAC
CCCAACCCAAGGTATCCGAGATGATGCGAGGCAAGTTTCGCGGCATCAGTGAGACCAAGATGATCGATTGCCTGGCGCGA
CTGGGGCGTGATATTCAGATTGTGATCAAGCCAGCGCCCCGCTCCCGTCGCGAAGGGCGAGTTGAAGTGATCATCACCTG
A
ATGACTGAGATCGAAACAGGCAGCGGGAACGTTTATGCCGACCTCAACAGTGCCGACGCCAATGAAATGCTGGTAAAGGC
ACAGCTTGCCAGCAAGATCTGCAGCATCATCAAGGCTCGTCATCTCACTCAGGTGCAGGCCGCAGCGGTACTTGGGTTAC
CCCAACCCAAGGTATCCGAGATGATGCGAGGCAAGTTTCGCGGCATCAGTGAGACCAAGATGATCGATTGCCTGGCGCGA
CTGGGGCGTGATATTCAGATTGTGATCAAGCCAGCGCCCCGCTCCCGTCGCGAAGGGCGAGTTGAAGTGATCATCACCTG
A
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|