Detailed information of TA system TA243450

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2012275..2012533
• Replicon: chromosome
• Accession: NZ_CP096834
• Organism: Escherichia coli strain PM4-5

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: MYF75_RS11395
• Protein ID: WP_000809168.1
• Coordinates: 2012381..2012533 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	2012275..2012332 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MYF75_RS11375	2007322..2008653	+	1332	Protein_1916	fimbria/pilus outer membrane usher protein	-
MYF75_RS11380	2008666..2009625	+	960	WP_000871667.1	hypothetical protein	-
MYF75_RS11385	2009664..2010563	-	900	WP_001300855.1	transcriptional activator NhaR	-
MYF75_RS11390	2010629..2011795	-	1167	WP_000681360.1	Na+/H+ antiporter NhaA	-
-	2012275..2012332	-	58	-	-	Antitoxin
MYF75_RS11395	2012381..2012533	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
MYF75_RS11400	2012637..2013767	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
MYF75_RS11405	2013856..2015772	-	1917	WP_000516135.1	molecular chaperone DnaK	-
MYF75_RS11410	2016149..2016553	+	405	WP_000843559.1	DUF2541 family protein	-
MYF75_RS11415	2016579..2017292	+	714	WP_001102383.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T243450 WP_000809168.1 NZ_CP096834:2012381-2012533 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T243450 NZ_OX352320:c1293841-1293548 [Rheinheimera sp. MM224]
ATGAAAGCTTTTGTGCTGAGCCAGAAAGCTATGGCCGACTTAAGAGCTATAGCTATCTTTACGGAACAACGTTGGGGAAA
ACAGCAGCGCAATTTATACATCAAGCAGTTTGATGATGCTTTTCATCTGTTGGCCAAAACACCAATGGCGGGGAAAACCT
GCGATTACATCAAACAAGGCTATCGCAAATTCCCACAAGGCAGCCATCTGATTTTTTATAAAGATAGTGGCAGTGGACAG
ATTGAAATTGTGCGTATTTTGCATAAGAACGTGGATACTGAGGCAAAGTTTTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT243450 NZ_CP096834:c2012332-2012275 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin