Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1347265..1348060 Replicon chromosome
Accession NC_013364
Organism Escherichia coli O111:H- str. 11128

Toxin (Protein)


Gene name yeeV Uniprot ID B7UP43
Locus tag ECO111_RS06940 Protein ID WP_000854914.1
Coordinates 1347686..1348060 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0B0VS41
Locus tag ECO111_RS06935 Protein ID WP_001280954.1
Coordinates 1347265..1347639 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECO111_RS06900 1344272..1344592 + 321 WP_000149392.1 phospholipase -
ECO111_RS06910 1344932..1345750 + 819 WP_001234682.1 DUF945 domain-containing protein -
ECO111_RS06915 1345841..1346326 + 486 WP_000214398.1 antirestriction protein -
ECO111_RS06920 1346342..1346818 + 477 WP_001186738.1 RadC family protein -
ECO111_RS06925 1346881..1347102 + 222 WP_001220314.1 DUF987 domain-containing protein -
ECO111_RS06935 1347265..1347639 + 375 WP_001280954.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
ECO111_RS06940 1347686..1348060 + 375 WP_000854914.1 TA system toxin CbtA family protein Toxin
ECO111_RS06945 1348057..1348548 + 492 WP_000976857.1 hypothetical protein -
ECO111_RS06950 1348560..1348757 + 198 WP_000839282.1 DUF957 domain-containing protein -
ECO111_RS06955 1348842..1349684 + 843 WP_001280481.1 DUF4942 domain-containing protein -
ECO111_RS06965 1350155..1351093 + 939 WP_000351317.1 glyoxylate/hydroxypyruvate reductase GhrA -
ECO111_RS06970 1351148..1351885 + 738 WP_000283664.1 zinc-binding phosphatase -
ECO111_RS06975 1351909..1352463 + 555 WP_001001902.1 molecular chaperone YcdY -
ECO111_RS06980 1352565..1353056 + 492 WP_042352365.1 DUF1097 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - csgG / csgF / csgE / csgD / csgB / csgA / csgC 1346342..1358621 12279


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14117.17 Da        Isoelectric Point: 7.7761

>T24344 WP_000854914.1 NC_013364:1347686-1348060 [Escherichia coli O111:H- str. 11128]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T24344 NC_013364:1347686-1348060 [Escherichia coli O111:H- str. 11128]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13718.51 Da        Isoelectric Point: 6.6249

>AT24344 WP_001280954.1 NC_013364:1347265-1347639 [Escherichia coli O111:H- str. 11128]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLNAKGLTCEADTLGSCGYVYLAVYPTPAPATTS

Download         Length: 375 bp

>AT24344 NC_013364:1347265-1347639 [Escherichia coli O111:H- str. 11128]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGAATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LXR5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0VS41

References