Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 58998..59262 | Replicon | plasmid pPM4-5-ndm-5 |
| Accession | NZ_CP096831 | ||
| Organism | Escherichia coli strain PM4-5 | ||
Toxin (Protein)
| Gene name | pndA | Uniprot ID | U9Y6M3 |
| Locus tag | MYF75_RS00355 | Protein ID | WP_001331364.1 |
| Coordinates | 59110..59262 (+) | Length | 51 a.a. |
Antitoxin (RNA)
| Gene name | pndB | ||
| Locus tag | - | ||
| Coordinates | 58998..59055 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MYF75_RS00340 (54237) | 54237..56528 | - | 2292 | WP_001289272.1 | F-type conjugative transfer protein TrbC | - |
| MYF75_RS00345 (56521) | 56521..57591 | - | 1071 | WP_001535705.1 | IncI1-type conjugal transfer protein TrbB | - |
| MYF75_RS00350 (57610) | 57610..58818 | - | 1209 | WP_001535704.1 | IncI1-type conjugal transfer protein TrbA | - |
| - (58998) | 58998..59055 | - | 58 | NuclAT_0 | - | Antitoxin |
| - (58998) | 58998..59055 | - | 58 | NuclAT_0 | - | Antitoxin |
| - (58998) | 58998..59055 | - | 58 | NuclAT_0 | - | Antitoxin |
| - (58998) | 58998..59055 | - | 58 | NuclAT_0 | - | Antitoxin |
| MYF75_RS00355 (59110) | 59110..59262 | + | 153 | WP_001331364.1 | Hok/Gef family protein | Toxin |
| MYF75_RS00360 (59334) | 59334..59585 | - | 252 | WP_226526250.1 | hypothetical protein | - |
| MYF75_RS25800 (60086) | 60086..60181 | + | 96 | WP_000609148.1 | DinQ-like type I toxin DqlB | - |
| MYF75_RS00370 (60246) | 60246..60422 | - | 177 | WP_001054904.1 | hypothetical protein | - |
| MYF75_RS00375 (60631) | 60631..60840 | - | 210 | WP_001140545.1 | hemolysin expression modulator Hha | - |
| MYF75_RS00380 (60938) | 60938..61552 | - | 615 | WP_000578649.1 | plasmid IncI1-type surface exclusion protein ExcA | - |
| MYF75_RS00385 (61628) | 61628..63796 | - | 2169 | WP_000698360.1 | IncI1-type conjugal transfer membrane protein TraY | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | blaNDM-5 / sul1 / qacE | - | 1..106484 | 106484 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 51 a.a. Molecular weight: 5775.13 Da Isoelectric Point: 8.7948
>T243433 WP_001331364.1 NZ_CP096831:59110-59262 [Escherichia coli]
MPQRTFLMMLIVICVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR
MPQRTFLMMLIVICVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR
Download Length: 153 bp
>T243433 NZ_OX344719:c1120958-1120713 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG
Antitoxin
Download Length: 58 bp
>AT243433 NZ_CP096831:c59055-58998 [Escherichia coli]
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
GCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
