Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3150804..3151464 Replicon chromosome
Accession NZ_CP096821
Organism Pectobacterium sp. 21LCBS03

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MYB54_RS14170 Protein ID WP_180788117.1
Coordinates 3151111..3151464 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MYB54_RS14165 Protein ID WP_014914856.1
Coordinates 3150804..3151106 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MYB54_RS14140 (MYB54_14140) 3145926..3147362 - 1437 WP_248720933.1 glycoside hydrolase family 1 protein -
MYB54_RS14145 (MYB54_14145) 3147566..3148021 - 456 WP_039287413.1 helix-turn-helix domain-containing protein -
MYB54_RS14150 (MYB54_14150) 3148088..3149347 + 1260 WP_248720934.1 MFS transporter -
MYB54_RS14155 (MYB54_14155) 3149359..3149709 - 351 WP_014914858.1 metalloregulator ArsR/SmtB family transcription factor -
MYB54_RS14160 (MYB54_14160) 3149762..3150766 + 1005 WP_248720935.1 threonine/serine dehydratase -
MYB54_RS14165 (MYB54_14165) 3150804..3151106 - 303 WP_014914856.1 helix-turn-helix transcriptional regulator Antitoxin
MYB54_RS14170 (MYB54_14170) 3151111..3151464 - 354 WP_180788117.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MYB54_RS14175 (MYB54_14175) 3151688..3152128 - 441 WP_039500392.1 helix-turn-helix domain-containing protein -
MYB54_RS14180 (MYB54_14180) 3152231..3152842 + 612 WP_039287426.1 NAD(P)-dependent oxidoreductase -
MYB54_RS14185 (MYB54_14185) 3153008..3153847 + 840 WP_039508969.1 glutathione-dependent disulfide-bond oxidoreductase -
MYB54_RS14190 (MYB54_14190) 3153907..3155151 - 1245 WP_205567946.1 multidrug effflux MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13620.76 Da        Isoelectric Point: 10.0708

>T243415 WP_180788117.1 NZ_CP096821:c3151464-3151111 [Pectobacterium sp. 21LCBS03]
VWKIEMTDVFDSWFSTLNDRDRAYVLAALIVLREKGPMLSRPYADTVKGSRYFNMKELRIQSGGMPIRAFFAFDPHRTGI
LLCAGNKSGNEKRFYDEMIPLADREFTKYLKKSEKRG

Download         Length: 354 bp

>T243415 NZ_OX335040:3369306-3369899 [Alteromonas macleodii]
GTGCATCGCAATAATATCCCGTGGATATTAGATAATGGTCTTTATTGTGGTAATAGCCATGTCCAGTCACCTAATTGGGA
GGCCATAGGTAATTCGGAACTCATACAGAAACGCGCCACTCACCCAGTCCCCATATCACCATTTGGCTCTTTAAATGACT
ATGTGCCTTTCTATTTTACCCCGTTTTCCCCCATGTTGCTCAATATCAAGTCTGGACGGGGGGTTAAGCAGAGGGCTAAC
GAAGATATCGTTATATTGGTATCATCATTACACAAAGTTGAACAACTAAACTTAGATTTTGTCTATACGGACATGCATGC
ATATTATCAGTGGGCGAGTTTTTACTCGGATTTGAATCACTTGGGTGAAGTAGATTGGCCTATATTACAAACGCGGAATT
TTGCCAGAGATCTCAACGACCCAGCCAAGTTTGAACGATATCAAGCAGAAGCATTGGTAAAGCAGCATTGTCCAATAAAT
GCTTTAGTAGGTATAGCTTGTTACAATACTCGAGTTGAACAAGAGTTAAAACATCATATTCAACAGCGCAATATGAATTT
AGACGTAATTGTACGTCCAGGATGGTACTTCTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11093.88 Da        Isoelectric Point: 6.2269

>AT243415 WP_014914856.1 NZ_CP096821:c3151106-3150804 [Pectobacterium sp. 21LCBS03]
MGRTLEQLLADEKPDVVVDAHAIAADMLLNIHLAELRERVQKTQVEMAQVLGLKQPTIAGMEKPGRDLKLSTLKRYVEAT
GSKLRLDVELPDGSHYGFTL

Download         Length: 303 bp

>AT243415 NZ_OX335040:3369899-3370963 [Alteromonas macleodii]
ATGATCACTTATACGCAAGGTAATTTACTCGAAGCACAAGTAGAGGCACTCGTTAACACTGTAAATACAGTTGGAGTTAT
GGGGAAAGGTATTGCACTAATGTTCAAAGAGCGCTTTCCCAAAAACATGGCTGAATATGCTAGTGCTTGCAAAGCTAAGC
AGGTAAATACAGGTAAAATGTTTGTTACTGAAACTAGTGAGTTGATGGGTCCTAAGTGGATTGTTAATTTTCCTACTAAG
CAGCATTGGCGTGCAAAATCTAAAATGGAGTGGATCCAAGAGGGCTTAATCGATCTTCGATATTTCTTAGAAAACAACAA
TGTCCGATCAATAGCTATTCCGCCACTTGGTGCGGGACAGGGTGGACTAGCCTGGCCAGATGTAAAAATGGAGATCGAAA
AGGCTTTATCAGACATTAAAACCACAAATATTATTGTGTTTGAGCCTACCAGTAAATATCAAAACGTGGCCAAGGCATCA
GGTGTTAAGAAACTTACTCCAGCGCGAGCATTAGTTGCAGAATTAGTGAGGCGCTATTGGATTTTGGGTATGGAATGTAG
TTTGTTGGAGATTCAAAAACTCGCTTGGTTTTTACAAAGAACAATCGAAAAAAGAGGGTTAAAAAACGAATTAAAACTGA
AATTTGAAGCAAATTATTATGGACCATATGCCAATAATCTAGACCATTTACTAAATGCTCTAGATGGTAGTTATTTGAAA
TCTGATAAACGAATTCCTGATTGCGACCCGTTGGATGTGATTTGGTTTAATGAATCAGAAAAGCAAAAAATTTCAACGTA
CTTGAATACAGAAGCCAAAGAATATTTACCCGCACTCGAGGGCGCAACTCAAGTAATCAGCGGTTTCGAATCCCCTTTTG
GTTTAGAGCTTCTATCTACAGTAGATTGGTTAGTTACTAACCAAGGCTGTGAAAGGACTGTTGAATCTATTAAAGAAGGT
ATAGCTAATTGGCCTGCTGGAGCTAAATGGGCGCAAAGAAAATTTAACTTATTTAGCAATAAAGATATTGAATTTGCTTT
AACTAATTTGGAAATTCTAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References