Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/RelE-HTH |
| Location | 5908..6493 | Replicon | plasmid unnamed2 |
| Accession | NZ_CP096820 | ||
| Organism | Acinetobacter baumannii strain Mu1984 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | N8ZPD7 |
| Locus tag | M1R67_RS19445 | Protein ID | WP_000897309.1 |
| Coordinates | 6173..6493 (-) | Length | 107 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | M1R67_RS19440 | Protein ID | WP_000369780.1 |
| Coordinates | 5908..6180 (-) | Length | 91 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M1R67_RS19410 (M1R67_19400) | 944..1519 | + | 576 | WP_001096619.1 | plasmid replication DNA-binding protein | - |
| M1R67_RS19415 (M1R67_19405) | 1539..1682 | + | 144 | WP_001125246.1 | hypothetical protein | - |
| M1R67_RS19420 (M1R67_19410) | 1988..2263 | + | 276 | WP_001133626.1 | metal/formaldehyde-sensitive transcriptional repressor | - |
| M1R67_RS19425 (M1R67_19415) | 2285..3394 | + | 1110 | WP_000842148.1 | S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase | - |
| M1R67_RS19430 (M1R67_19420) | 3447..3845 | + | 399 | WP_000235176.1 | VOC family protein | - |
| M1R67_RS19435 (M1R67_19425) | 4319..5152 | + | 834 | WP_000439570.1 | S-formylglutathione hydrolase | - |
| M1R67_RS19440 (M1R67_19430) | 5908..6180 | - | 273 | WP_000369780.1 | NadS family protein | Antitoxin |
| M1R67_RS19445 (M1R67_19435) | 6173..6493 | - | 321 | WP_000897309.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| M1R67_RS19450 (M1R67_19440) | 6680..6877 | - | 198 | WP_000476222.1 | hypothetical protein | - |
| M1R67_RS19455 (M1R67_19445) | 6944..7171 | - | 228 | WP_000921865.1 | hypothetical protein | - |
| M1R67_RS19460 (M1R67_19450) | 7270..7485 | - | 216 | WP_000071892.1 | cold-shock protein | - |
| M1R67_RS19465 (M1R67_19455) | 7930..8898 | - | 969 | WP_012308653.1 | IS30 family transposase | - |
| M1R67_RS19470 (M1R67_19460) | 9000..9332 | - | 333 | WP_000390243.1 | hypothetical protein | - |
| M1R67_RS19475 (M1R67_19465) | 9350..9616 | - | 267 | WP_050441450.1 | hypothetical protein | - |
| M1R67_RS19480 (M1R67_19470) | 9826..11261 | + | 1436 | Protein_15 | MobQ family relaxase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..11805 | 11805 | |
| - | flank | IS/Tn | - | - | 7930..8955 | 1025 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 107 a.a. Molecular weight: 12209.01 Da Isoelectric Point: 7.9835
>T243412 WP_000897309.1 NZ_CP096820:c6493-6173 [Acinetobacter baumannii]
MLFIETSIFTKQIKELVSDEEYRQLQQDLLVQPDKGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSVKDNLTDKETSILRQLVKEQFHG
MLFIETSIFTKQIKELVSDEEYRQLQQDLLVQPDKGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSVKDNLTDKETSILRQLVKEQFHG
Download Length: 321 bp
>T243412 NZ_OX281345:1454141-1454545 [Thermococcus nautili]
ATGAAGCTCTTCATTGATACCAACCTTTTTGTTTACCTCCTGACCAAGACGCCTGAAGACGAAAAGAAGATAGTCACGTT
CTACGCCGAACTGATTGAGAATCACGACCTTTACACAAGTCCGCTGGTTCTTGACGAGACCATTCACGTTGCAAAGAAGA
AATACGGCGTCCATTACGAGCTTTCGATTGAGTTCATAGACGAAAAGGTTCTTCCCTACGTTGAAGTTCTTCCTCTGACT
GTCTTTGATTATCTAACCGCCAGACTGATAATCACGAAATACAACCTCCGCCCCTCTGACGCCCTCCACGTTGCGGTTAT
AGAGAACAACGGTCTTCAGGCCATAGTTAGCGAGGATGAGGATTTTGACGTTCTCCCGCTCAAACGGGTCTGGCTGGGTG
GTTGA
ATGAAGCTCTTCATTGATACCAACCTTTTTGTTTACCTCCTGACCAAGACGCCTGAAGACGAAAAGAAGATAGTCACGTT
CTACGCCGAACTGATTGAGAATCACGACCTTTACACAAGTCCGCTGGTTCTTGACGAGACCATTCACGTTGCAAAGAAGA
AATACGGCGTCCATTACGAGCTTTCGATTGAGTTCATAGACGAAAAGGTTCTTCCCTACGTTGAAGTTCTTCCTCTGACT
GTCTTTGATTATCTAACCGCCAGACTGATAATCACGAAATACAACCTCCGCCCCTCTGACGCCCTCCACGTTGCGGTTAT
AGAGAACAACGGTCTTCAGGCCATAGTTAGCGAGGATGAGGATTTTGACGTTCTCCCGCTCAAACGGGTCTGGCTGGGTG
GTTGA
Antitoxin
Download Length: 91 a.a. Molecular weight: 10122.63 Da Isoelectric Point: 8.6582
>AT243412 WP_000369780.1 NZ_CP096820:c6180-5908 [Acinetobacter baumannii]
MDNNLFDDLVASIKEAGAIKRKEIKASRVTELELPDIKEVREKTGLTQAEFAARLHISARTLQNWEQGRRYPTGPAATLI
RILDAHPTLI
MDNNLFDDLVASIKEAGAIKRKEIKASRVTELELPDIKEVREKTGLTQAEFAARLHISARTLQNWEQGRRYPTGPAATLI
RILDAHPTLI
Download Length: 273 bp
>AT243412 NZ_OX281345:1453860-1454144 [Thermococcus nautili]
GTGATACCTTTGGTTAGCATACGCCTCAAGGTCGGCCCCAAGGGGCAGATTGTCATCCCCAAGGTCTTCCGTGAAGCTTA
TGGCATAAAGGAAGGCGGAGAGGTTATAGTTGAGCCTACCGATAAGGGACTGATAATTATGCCCAAGAAGAGCAAAGAAG
AGCTGATTAAAGAGCTCCTCGAATGGAAGCACAAGAGAGCCAAAGGCAAGCCCGCCAAACTTGGAGAGCTGAAGGGAATA
AGCCTCGAAGACGAGTTCGACGAGGTCTGGGGGATTGAGGAATGA
GTGATACCTTTGGTTAGCATACGCCTCAAGGTCGGCCCCAAGGGGCAGATTGTCATCCCCAAGGTCTTCCGTGAAGCTTA
TGGCATAAAGGAAGGCGGAGAGGTTATAGTTGAGCCTACCGATAAGGGACTGATAATTATGCCCAAGAAGAGCAAAGAAG
AGCTGATTAAAGAGCTCCTCGAATGGAAGCACAAGAGAGCCAAAGGCAAGCCCGCCAAACTTGGAGAGCTGAAGGGAATA
AGCCTCGAAGACGAGTTCGACGAGGTCTGGGGGATTGAGGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|