Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/RelE-HTH |
| Location | 5347281..5347955 | Replicon | chromosome |
| Accession | NZ_CP096810 | ||
| Organism | Klebsiella pneumoniae strain Bio19 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A5Q9LMS5 |
| Locus tag | MOV22_RS26035 | Protein ID | WP_032720638.1 |
| Coordinates | 5347632..5347955 (-) | Length | 108 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | MOV22_RS26030 | Protein ID | WP_032720637.1 |
| Coordinates | 5347281..5347583 (-) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MOV22_RS25980 (5342287) | 5342287..5342352 | + | 66 | Protein_5114 | EAL domain-containing protein | - |
| MOV22_RS25985 (5342492) | 5342492..5343256 | - | 765 | WP_001389365.1 | IS6-like element IS6100 family transposase | - |
| MOV22_RS25990 (5343374) | 5343374..5343439 | - | 66 | Protein_5116 | EAL domain-containing protein | - |
| MOV22_RS25995 (5343513) | 5343513..5343665 | - | 153 | Protein_5117 | plasmid mobilization relaxosome protein MobC | - |
| MOV22_RS26000 (5343886) | 5343886..5344359 | - | 474 | WP_004201280.1 | trimethoprim-resistant dihydrofolate reductase DfrA14 | - |
| MOV22_RS26005 (5344515) | 5344515..5345528 | + | 1014 | WP_000845048.1 | class 1 integron integrase IntI1 | - |
| MOV22_RS26010 (5346074) | 5346074..5346148 | + | 75 | Protein_5120 | IS6 family transposase | - |
| MOV22_RS26015 (5346297) | 5346297..5346680 | + | 384 | WP_032720636.1 | hypothetical protein | - |
| MOV22_RS26020 (5346677) | 5346677..5346883 | + | 207 | WP_153591439.1 | hypothetical protein | - |
| MOV22_RS26025 (5347071) | 5347071..5347238 | + | 168 | WP_153591440.1 | hypothetical protein | - |
| MOV22_RS26030 (5347281) | 5347281..5347583 | - | 303 | WP_032720637.1 | NadS family protein | Antitoxin |
| MOV22_RS26035 (5347632) | 5347632..5347955 | - | 324 | WP_032720638.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| MOV22_RS28490 (5348133) | 5348133..5348285 | - | 153 | WP_269233002.1 | DUF4113 domain-containing protein | - |
| MOV22_RS28495 (5348317) | 5348317..5348451 | + | 135 | WP_269233001.1 | hypothetical protein | - |
| MOV22_RS26045 (5348516) | 5348516..5348943 | + | 428 | Protein_5128 | DNA-binding protein | - |
| MOV22_RS26050 (5349012) | 5349012..5349614 | - | 603 | Protein_5129 | RNA-guided endonuclease TnpB family protein | - |
| MOV22_RS26055 (5350115) | 5350115..5350438 | - | 324 | WP_019725650.1 | hypothetical protein | - |
| MOV22_RS26060 (5350511) | 5350511..5351506 | - | 996 | WP_019725651.1 | hypothetical protein | - |
| MOV22_RS26065 (5351803) | 5351803..5352453 | - | 651 | WP_015065500.1 | SOS response-associated peptidase | - |
| MOV22_RS26070 (5352500) | 5352500..5352895 | - | 396 | WP_019725652.1 | recombinase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | tufA | 5341017..5396147 | 55130 | |
| - | flank | IS/Tn | - | - | 5342492..5343256 | 764 | |
| - | flank | IS/Tn | - | - | 5349012..5349410 | 398 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 108 a.a. Molecular weight: 12372.29 Da Isoelectric Point: 9.6240
>T243375 WP_032720638.1 NZ_CP096810:c5347955-5347632 [Klebsiella pneumoniae]
MNYLEFVETSAFSGLRKELMDDDEFRELQTYLLEAHDRGDTISHTGGCRKIRWGRPGMGKRGGVRVIYYVRLASGRLYLL
LIYPKNAKDELSEKEKAVMKALTQQLK
MNYLEFVETSAFSGLRKELMDDDEFRELQTYLLEAHDRGDTISHTGGCRKIRWGRPGMGKRGGVRVIYYVRLASGRLYLL
LIYPKNAKDELSEKEKAVMKALTQQLK
Download Length: 324 bp
>T243375 NZ_OX030701:4141036-4141338 [Escherichia coli]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11211.12 Da Isoelectric Point: 7.3611
>AT243375 WP_032720637.1 NZ_CP096810:c5347583-5347281 [Klebsiella pneumoniae]
MEKKLFDALISSMEEMVAIENGQIQPAAEQVHRHTLPDVKAIRKHAGMKQAEFAEVVGASVDLVRSWEQQRRVPSGIALK
MLCLIEREPALINTLRGIHV
MEKKLFDALISSMEEMVAIENGQIQPAAEQVHRHTLPDVKAIRKHAGMKQAEFAEVVGASVDLVRSWEQQRRVPSGIALK
MLCLIEREPALINTLRGIHV
Download Length: 303 bp
>AT243375 NZ_OX030701:4141374-4141715 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|