Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 25986..26644 Replicon plasmid p5651
Accession NZ_CP096763
Organism Acinetobacter baumannii strain 5651

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag M1S22_RS19005 Protein ID WP_000312250.1
Coordinates 26285..26644 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M1S22_RS19000 Protein ID WP_001096429.1
Coordinates 25986..26285 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1S22_RS18955 (M1S22_18955) 21023..21280 + 258 WP_000834292.1 hypothetical protein -
M1S22_RS18960 (M1S22_18960) 21285..21857 + 573 WP_038345812.1 hypothetical protein -
M1S22_RS18965 (M1S22_18965) 21833..22012 + 180 WP_002081921.1 hypothetical protein -
M1S22_RS18970 (M1S22_18970) 22029..22658 + 630 WP_002081923.1 hypothetical protein -
M1S22_RS18975 (M1S22_18975) 22698..23207 + 510 WP_001043199.1 hypothetical protein -
M1S22_RS18980 (M1S22_18980) 23288..23842 + 555 WP_038345807.1 hypothetical protein -
M1S22_RS18985 (M1S22_18985) 23892..24428 + 537 WP_000731981.1 hypothetical protein -
M1S22_RS18990 (M1S22_18990) 25049..25384 + 336 WP_249379612.1 hypothetical protein -
M1S22_RS18995 (M1S22_18995) 25622..25885 - 264 WP_000110863.1 hypothetical protein -
M1S22_RS19000 (M1S22_19000) 25986..26285 - 300 WP_001096429.1 XRE family transcriptional regulator Antitoxin
M1S22_RS19005 (M1S22_19005) 26285..26644 - 360 WP_000312250.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M1S22_RS19010 (M1S22_19010) 26845..27411 + 567 WP_000710385.1 hypothetical protein -
M1S22_RS19015 (M1S22_19015) 27460..27642 + 183 WP_000373385.1 hypothetical protein -
M1S22_RS19020 (M1S22_19020) 27709..28407 + 699 WP_000873188.1 hypothetical protein -
M1S22_RS19025 (M1S22_19025) 28546..28929 + 384 WP_000654348.1 hypothetical protein -
M1S22_RS19030 (M1S22_19030) 28996..29754 + 759 WP_001053128.1 hypothetical protein -
M1S22_RS19035 (M1S22_19035) 29806..30141 + 336 WP_000653925.1 hypothetical protein -
M1S22_RS19040 (M1S22_19040) 31008..31322 + 315 WP_000708715.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..72248 72248


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-109)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-88)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13751.62 Da        Isoelectric Point: 4.8212

>T243333 WP_000312250.1 NZ_CP096763:c26644-26285 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Download         Length: 360 bp

>T243333 NZ_OW970553:c4667138-4666605 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11012.93 Da        Isoelectric Point: 10.4856

>AT243333 WP_001096429.1 NZ_CP096763:c26285-25986 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Download         Length: 300 bp

>AT243333 NZ_OW970553:c4667415-4667149 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References