Detailed information of TA system TA243324

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 10554..11212
• Replicon: plasmid p5664
• Accession: NZ_CP096754
• Organism: Acinetobacter baumannii strain 5664

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: M1S46_RS19730
• Protein ID: WP_000312250.1
• Coordinates: 10853..11212 (-)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: M1S46_RS19725
• Protein ID: WP_001096429.1
• Coordinates: 10554..10853 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1S46_RS19690 (M1S46_19690)	6612..6869	+	258	WP_071210684.1	hypothetical protein	-
M1S46_RS19695 (M1S46_19695)	6874..7446	+	573	WP_071210685.1	hypothetical protein	-
M1S46_RS19700 (M1S46_19700)	7422..7601	+	180	WP_002081921.1	hypothetical protein	-
M1S46_RS19705 (M1S46_19705)	7618..8247	+	630	WP_071210686.1	hypothetical protein	-
M1S46_RS19710 (M1S46_19710)	8287..8796	+	510	WP_001043200.1	hypothetical protein	-
M1S46_RS19715 (M1S46_19715)	8877..9431	+	555	WP_071210687.1	hypothetical protein	-
M1S46_RS19720 (M1S46_19720)	9481..10017	+	537	WP_000731980.1	hypothetical protein	-
M1S46_RS19725 (M1S46_19725)	10554..10853	-	300	WP_001096429.1	XRE family transcriptional regulator	Antitoxin
M1S46_RS19730 (M1S46_19730)	10853..11212	-	360	WP_000312250.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
M1S46_RS19735 (M1S46_19735)	11413..11979	+	567	WP_000710385.1	hypothetical protein	-
M1S46_RS19740 (M1S46_19740)	12028..12210	+	183	WP_000373385.1	hypothetical protein	-
M1S46_RS19745 (M1S46_19745)	12277..12975	+	699	WP_000873190.1	hypothetical protein	-
M1S46_RS19750 (M1S46_19750)	13114..13497	+	384	WP_071210698.1	hypothetical protein	-
M1S46_RS19755 (M1S46_19755)	13558..14316	+	759	WP_071210697.1	hypothetical protein	-
M1S46_RS19760 (M1S46_19760)	14367..14702	+	336	WP_071210696.1	hypothetical protein	-
M1S46_RS19765 (M1S46_19765)	15569..15883	+	315	WP_071210660.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..71044	71044

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (14-109)

Antitoxin

• HigA2-like, helix-turn-helix domain (12-88)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 13751.62 Da
• Isoelectric Point: 4.8212

>T243324 WP_000312250.1 NZ_CP096754:c11212-10853 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Nucleotide

• Length: 360 bp

>T243324 NZ_OW970542:c10078-9662 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACCAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGTGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCGTGGGACCGGGCT
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGCACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGACACGCCATCGCGGCGGGCGCCATCCTGGTGACGAATAATACAAGAGAGTTTGCGCGGGTCCCGGGCCTGGTGCTGG
AAGACTGGGTGAATTAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11012.93 Da
• Isoelectric Point: 10.4856

>AT243324 WP_001096429.1 NZ_CP096754:c10853-10554 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Nucleotide

• Length: 300 bp

>AT243324 NZ_OW970542:c10305-10075 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGTGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAACGCGAGGATGTGGTCAGCGACGAAGGACGCTTTGAGCCATGA