Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 11509..12167 Replicon plasmid p5671_2
Accession NZ_CP096744
Organism Acinetobacter baumannii strain 5671

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag M1S42_RS19825 Protein ID WP_000312250.1
Coordinates 11808..12167 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M1S42_RS19820 Protein ID WP_001096429.1
Coordinates 11509..11808 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1S42_RS19775 (M1S42_19775) 6542..6799 + 258 WP_000834292.1 hypothetical protein -
M1S42_RS19780 (M1S42_19780) 6804..7376 + 573 WP_000429351.1 hypothetical protein -
M1S42_RS19785 (M1S42_19785) 7352..7531 + 180 WP_002081921.1 hypothetical protein -
M1S42_RS19790 (M1S42_19790) 7548..8177 + 630 WP_002081923.1 hypothetical protein -
M1S42_RS19795 (M1S42_19795) 8217..8726 + 510 WP_001043199.1 hypothetical protein -
M1S42_RS19800 (M1S42_19800) 8807..9361 + 555 WP_000790085.1 hypothetical protein -
M1S42_RS19805 (M1S42_19805) 9411..9947 + 537 WP_000731981.1 hypothetical protein -
M1S42_RS19810 (M1S42_19810) 10570..11052 + 483 WP_001052677.1 hypothetical protein -
M1S42_RS19815 (M1S42_19815) 11145..11408 - 264 WP_000110863.1 hypothetical protein -
M1S42_RS19820 (M1S42_19820) 11509..11808 - 300 WP_001096429.1 XRE family transcriptional regulator Antitoxin
M1S42_RS19825 (M1S42_19825) 11808..12167 - 360 WP_000312250.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M1S42_RS19830 (M1S42_19830) 12368..12934 + 567 WP_041171756.1 hypothetical protein -
M1S42_RS19835 (M1S42_19835) 12983..13165 + 183 WP_000373385.1 hypothetical protein -
M1S42_RS19840 (M1S42_19840) 13232..13930 + 699 WP_000873190.1 hypothetical protein -
M1S42_RS19845 (M1S42_19845) 14069..14452 + 384 WP_000654349.1 hypothetical protein -
M1S42_RS19850 (M1S42_19850) 14519..15277 + 759 WP_001053129.1 hypothetical protein -
M1S42_RS19855 (M1S42_19855) 16347..16661 + 315 WP_000708714.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..71278 71278


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-109)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-88)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13751.62 Da        Isoelectric Point: 4.8212

>T243317 WP_000312250.1 NZ_CP096744:c12167-11808 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Download         Length: 360 bp

>T243317 NZ_OW970540:c2759137-2757815 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11012.93 Da        Isoelectric Point: 10.4856

>AT243317 WP_001096429.1 NZ_CP096744:c11808-11509 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Download         Length: 300 bp

>AT243317 NZ_OW970540:c2759403-2759137 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References