Detailed information of TA system TA243312

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 12397..13055
• Replicon: plasmid p5679
• Accession: NZ_CP096739
• Organism: Acinetobacter baumannii strain 5679

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: M1S39_RS19125
• Protein ID: WP_000312250.1
• Coordinates: 12696..13055 (-)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: M1S39_RS19120
• Protein ID: WP_001096429.1
• Coordinates: 12397..12696 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1S39_RS19085 (M1S39_19085)	7564..8193	+	630	WP_002081923.1	hypothetical protein	-
M1S39_RS19090 (M1S39_19090)	8233..8742	+	510	WP_001043199.1	hypothetical protein	-
M1S39_RS19095 (M1S39_19095)	8824..9336	+	513	WP_000840065.1	hypothetical protein	-
M1S39_RS19100 (M1S39_19100)	9392..9721	+	330	WP_000459117.1	hypothetical protein	-
M1S39_RS19105 (M1S39_19105)	9758..10486	+	729	WP_001022819.1	hypothetical protein	-
M1S39_RS19110 (M1S39_19110)	10915..11274	+	360	WP_223234021.1	hypothetical protein	-
M1S39_RS19115 (M1S39_19115)	11324..11860	+	537	WP_060853649.1	hypothetical protein	-
M1S39_RS19120 (M1S39_19120)	12397..12696	-	300	WP_001096429.1	XRE family transcriptional regulator	Antitoxin
M1S39_RS19125 (M1S39_19125)	12696..13055	-	360	WP_000312250.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
M1S39_RS19130 (M1S39_19130)	13256..13822	+	567	WP_031948745.1	hypothetical protein	-
M1S39_RS19135 (M1S39_19135)	13871..14053	+	183	WP_000373384.1	hypothetical protein	-
M1S39_RS19140 (M1S39_19140)	14120..14818	+	699	WP_000873188.1	hypothetical protein	-
M1S39_RS19145 (M1S39_19145)	14957..15340	+	384	WP_000654347.1	hypothetical protein	-
M1S39_RS19150 (M1S39_19150)	15407..16165	+	759	WP_060853650.1	hypothetical protein	-
M1S39_RS19155 (M1S39_19155)	16217..16552	+	336	WP_000654055.1	hypothetical protein	-
M1S39_RS19160 (M1S39_19160)	17417..17731	+	315	WP_000708713.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..73209	73209

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (14-109)

Antitoxin

• HigA2-like, helix-turn-helix domain (12-88)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 13751.62 Da
• Isoelectric Point: 4.8212

>T243312 WP_000312250.1 NZ_CP096739:c13055-12696 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Nucleotide

• Length: 360 bp

>T243312 NZ_OW970540:356941-357288 [Klebsiella pneumoniae]
ATGTGGGATGTGGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCTTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATAAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11012.93 Da
• Isoelectric Point: 10.4856

>AT243312 WP_001096429.1 NZ_CP096739:c12696-12397 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Nucleotide

• Length: 300 bp

>AT243312 NZ_OW970540:357288-357587 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGACTGATAACGACCCTCGGCTTTCGACCCTAAAAAGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA