Detailed information of TA system TA243299

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 10530..11188
• Replicon: plasmid p5741_2
• Accession: NZ_CP096719
• Organism: Acinetobacter baumannii strain 5741

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: M1S14_RS19775
• Protein ID: WP_000312250.1
• Coordinates: 10829..11188 (-)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: M1S14_RS19770
• Protein ID: WP_001096429.1
• Coordinates: 10530..10829 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1S14_RS19735 (M1S14_19735)	6591..6848	+	258	WP_000834292.1	hypothetical protein	-
M1S14_RS19740 (M1S14_19740)	6853..7425	+	573	WP_032011345.1	hypothetical protein	-
M1S14_RS19745 (M1S14_19745)	7401..7580	+	180	WP_002081921.1	hypothetical protein	-
M1S14_RS19750 (M1S14_19750)	7597..8226	+	630	WP_002081923.1	hypothetical protein	-
M1S14_RS19755 (M1S14_19755)	8266..8775	+	510	WP_032018705.1	hypothetical protein	-
M1S14_RS19760 (M1S14_19760)	8856..9410	+	555	WP_000790086.1	hypothetical protein	-
M1S14_RS19765 (M1S14_19765)	9460..9996	+	537	WP_032010581.1	hypothetical protein	-
M1S14_RS19770 (M1S14_19770)	10530..10829	-	300	WP_001096429.1	XRE family transcriptional regulator	Antitoxin
M1S14_RS19775 (M1S14_19775)	10829..11188	-	360	WP_000312250.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
M1S14_RS19780 (M1S14_19780)	11389..11955	+	567	WP_031948745.1	hypothetical protein	-
M1S14_RS19785 (M1S14_19785)	12004..12234	+	231	WP_045124240.1	hypothetical protein	-
M1S14_RS19790 (M1S14_19790)	12253..12951	+	699	WP_000873188.1	hypothetical protein	-
M1S14_RS19795 (M1S14_19795)	13089..13472	+	384	WP_032018724.1	hypothetical protein	-
M1S14_RS19800 (M1S14_19800)	13539..14297	+	759	WP_001053130.1	hypothetical protein	-
M1S14_RS19805 (M1S14_19805)	14349..14684	+	336	WP_000654056.1	hypothetical protein	-
M1S14_RS19810 (M1S14_19810)	15550..15864	+	315	WP_032011240.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..70793	70793

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (14-109)

Antitoxin

• HigA2-like, helix-turn-helix domain (12-88)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 13751.62 Da
• Isoelectric Point: 4.8212

>T243299 WP_000312250.1 NZ_CP096719:c11188-10829 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Nucleotide

• Length: 360 bp

>T243299 NZ_OW970530:835190-835600 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11012.93 Da
• Isoelectric Point: 10.4856

>AT243299 WP_001096429.1 NZ_CP096719:c10829-10530 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Nucleotide

• Length: 300 bp

>AT243299 NZ_OW970530:834943-835209 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA