243288

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 16036..16687 Replicon plasmid p5759_3
Accession NZ_CP096713
Organism Acinetobacter baumannii strain 5759

Toxin (Protein)


Gene name higB Uniprot ID N8YFZ1
Locus tag M1S21_RS20695 Protein ID WP_000269904.1
Coordinates 16036..16392 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M1S21_RS20700 Protein ID WP_001129974.1
Coordinates 16385..16687 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1S21_RS20675 (M1S21_20675) 11289..12224 - 936 WP_001292329.1 replication initiation protein RepM -
M1S21_RS20680 (M1S21_20680) 12820..13989 - 1170 WP_002134206.1 MobA/MobL family protein -
M1S21_RS20685 (M1S21_20685) 14281..15054 + 774 WP_249374353.1 hypothetical protein -
M1S21_RS20690 (M1S21_20690) 15171..15470 + 300 WP_000358348.1 hypothetical protein -
M1S21_RS20695 (M1S21_20695) 16036..16392 + 357 WP_000269904.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M1S21_RS20700 (M1S21_20700) 16385..16687 + 303 WP_001129974.1 XRE family transcriptional regulator Antitoxin
M1S21_RS20705 (M1S21_20705) 16680..16889 + 210 WP_000069474.1 hypothetical protein -
M1S21_RS20710 (M1S21_20710) 17215..17676 - 462 WP_000761346.1 DIP1984 family protein -
M1S21_RS20715 (M1S21_20715) 17981..20392 - 2412 WP_000932953.1 TonB-dependent receptor ZnuD2 -
M1S21_RS20720 (M1S21_20720) 20520..20834 - 315 WP_001983304.1 BrnA antitoxin family protein -
M1S21_RS20725 (M1S21_20725) 20821..21108 - 288 WP_000438827.1 BrnT family toxin -
M1S21_RS20730 (M1S21_20730) 21376..21675 - 300 WP_000358348.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..33550 33550


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-81)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13488.42 Da        Isoelectric Point: 5.7104

>T243288 WP_000269904.1 NZ_CP096713:16036-16392 [Acinetobacter baumannii]
MWTVITTDLFNEWLEQQDEATQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKSNKKRFYTEMLAIADEQYALHLSTLGDQSNG

Download         Length: 357 bp

>T243288 NZ_OW970514:2026830-2026932 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11150.97 Da        Isoelectric Point: 7.3198

>AT243288 WP_001129974.1 NZ_CP096713:16385-16687 [Acinetobacter baumannii]
MAKSLQELLASRSPESQARIQKMADELLLESQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Download         Length: 303 bp

>AT243288 NZ_OW970514:c2026939-2026794 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB N8YFZ1

Antitoxin

Source ID Structure

References