243273

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2905..3556 Replicon plasmid p5773_1
Accession NZ_CP096694
Organism Acinetobacter baumannii strain 5773

Toxin (Protein)


Gene name higB Uniprot ID N8YFZ1
Locus tag M1S18_RS19140 Protein ID WP_000269904.1
Coordinates 2905..3261 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M1S18_RS19145 Protein ID WP_001129974.1
Coordinates 3254..3556 (+) Length 101 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1S18_RS19125 (M1S18_19125) 299..1234 + 936 WP_001292329.1 replication initiation protein RepM -
M1S18_RS19130 (M1S18_19130) 1312..1830 + 519 WP_000839337.1 plasmid replication DNA-binding protein -
M1S18_RS19135 (M1S18_19135) 2040..2339 + 300 WP_000358348.1 hypothetical protein -
M1S18_RS19140 (M1S18_19140) 2905..3261 + 357 WP_000269904.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M1S18_RS19145 (M1S18_19145) 3254..3556 + 303 WP_001129974.1 XRE family transcriptional regulator Antitoxin
M1S18_RS19150 (M1S18_19150) 3549..3758 + 210 WP_000069474.1 hypothetical protein -
M1S18_RS19155 (M1S18_19155) 4084..4545 - 462 WP_000761346.1 DIP1984 family protein -
M1S18_RS19160 (M1S18_19160) 4848..7250 - 2403 Protein_7 TonB-dependent receptor ZnuD2 -
M1S18_RS19165 (M1S18_19165) 7389..7682 - 294 Protein_8 BrnA antitoxin family protein -
M1S18_RS19170 (M1S18_19170) 7669..7952 - 284 Protein_9 BrnT family toxin -
M1S18_RS19175 (M1S18_19175) 8243..8554 - 312 WP_249377535.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..22354 22354


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-105)

Antitoxin

(31-81)


Sequences


Toxin        


Download         Length: 119 a.a.        Molecular weight: 13488.42 Da        Isoelectric Point: 5.7104

>T243273 WP_000269904.1 NZ_CP096694:2905-3261 [Acinetobacter baumannii]
MWTVITTDLFNEWLEQQDEATQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKSNKKRFYTEMLAIADEQYALHLSTLGDQSNG

Download         Length: 357 bp

>T243273 NZ_OW970492:1496750-1497166 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATTATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACCGACATCCGGGTGGCGCTGCACCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGCCACGCCATCGCGGCGGGCGCCGTCCTGGTGACGAACAATGTGAGAGAGTTTGCGCGGGTGCCTGGACTGACACTGG
AAGACTGGGTTATTTAG

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11150.97 Da        Isoelectric Point: 7.3198

>AT243273 WP_001129974.1 NZ_CP096694:3254-3556 [Acinetobacter baumannii]
MAKSLQELLASRSPESQARIQKMADELLLESQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Download         Length: 303 bp

>AT243273 NZ_OW970492:1496523-1496753 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAACGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB N8YFZ1


Antitoxin

Source ID Structure

References