Detailed information of TA system TA243270

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 11559..12217
• Replicon: plasmid p5839
• Accession: NZ_CP096691
• Organism: Acinetobacter baumannii strain 5839

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: M1S54_RS20050
• Protein ID: WP_000312250.1
• Coordinates: 11858..12217 (-)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: M1S54_RS20045
• Protein ID: WP_001096429.1
• Coordinates: 11559..11858 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1S54_RS20000 (M1S54_20000)	6592..6849	+	258	WP_000834292.1	hypothetical protein	-
M1S54_RS20005 (M1S54_20005)	6854..7426	+	573	WP_000429351.1	hypothetical protein	-
M1S54_RS20010 (M1S54_20010)	7402..7581	+	180	WP_002081921.1	hypothetical protein	-
M1S54_RS20015 (M1S54_20015)	7598..8227	+	630	WP_002081923.1	hypothetical protein	-
M1S54_RS20020 (M1S54_20020)	8267..8776	+	510	WP_001043199.1	hypothetical protein	-
M1S54_RS20025 (M1S54_20025)	8857..9411	+	555	WP_000790085.1	hypothetical protein	-
M1S54_RS20030 (M1S54_20030)	9461..9997	+	537	WP_000731981.1	hypothetical protein	-
M1S54_RS20035 (M1S54_20035)	10620..11102	+	483	WP_001052677.1	hypothetical protein	-
M1S54_RS20040 (M1S54_20040)	11195..11458	-	264	WP_000110863.1	hypothetical protein	-
M1S54_RS20045 (M1S54_20045)	11559..11858	-	300	WP_001096429.1	XRE family transcriptional regulator	Antitoxin
M1S54_RS20050 (M1S54_20050)	11858..12217	-	360	WP_000312250.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
M1S54_RS20055 (M1S54_20055)	12418..12984	+	567	WP_041171756.1	hypothetical protein	-
M1S54_RS20060 (M1S54_20060)	13033..13215	+	183	WP_000373385.1	hypothetical protein	-
M1S54_RS20065 (M1S54_20065)	13282..13980	+	699	WP_000873190.1	hypothetical protein	-
M1S54_RS20070 (M1S54_20070)	14119..14502	+	384	WP_000654349.1	hypothetical protein	-
M1S54_RS20075 (M1S54_20075)	14569..15327	+	759	WP_001053129.1	hypothetical protein	-
M1S54_RS20080 (M1S54_20080)	16397..16711	+	315	WP_000708714.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..71277	71277

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (14-109)

Antitoxin

• HigA2-like, helix-turn-helix domain (12-88)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 13751.62 Da
• Isoelectric Point: 4.8212

>T243270 WP_000312250.1 NZ_CP096691:c12217-11858 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Nucleotide

• Length: 360 bp

>T243270 NZ_OW970492:331748-332116 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGACAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11012.93 Da
• Isoelectric Point: 10.4856

>AT243270 WP_001096429.1 NZ_CP096691:c11858-11559 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Nucleotide

• Length: 300 bp

>AT243270 NZ_OW970492:331530-331751 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA