Detailed information of TA system TA243267

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 12430..13088
• Replicon: plasmid p5840
• Accession: NZ_CP096689
• Organism: Acinetobacter baumannii strain 5840

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: M1S41_RS19895
• Protein ID: WP_000312250.1
• Coordinates: 12729..13088 (-)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: M1S41_RS19890
• Protein ID: WP_001096429.1
• Coordinates: 12430..12729 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1S41_RS19855 (M1S41_19855)	7597..8226	+	630	WP_002081923.1	hypothetical protein	-
M1S41_RS19860 (M1S41_19860)	8266..8775	+	510	WP_001043199.1	hypothetical protein	-
M1S41_RS19865 (M1S41_19865)	8857..9369	+	513	WP_000840065.1	hypothetical protein	-
M1S41_RS19870 (M1S41_19870)	9425..9754	+	330	WP_000459117.1	hypothetical protein	-
M1S41_RS19875 (M1S41_19875)	9791..10519	+	729	WP_001022819.1	hypothetical protein	-
M1S41_RS20325	10754..10888	+	135	WP_256349227.1	hypothetical protein	-
M1S41_RS19880 (M1S41_19880)	10948..11307	+	360	WP_223234021.1	hypothetical protein	-
M1S41_RS19885 (M1S41_19885)	11357..11893	+	537	WP_060853649.1	hypothetical protein	-
M1S41_RS19890 (M1S41_19890)	12430..12729	-	300	WP_001096429.1	XRE family transcriptional regulator	Antitoxin
M1S41_RS19895 (M1S41_19895)	12729..13088	-	360	WP_000312250.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
M1S41_RS19900 (M1S41_19900)	13289..13855	+	567	WP_031948745.1	hypothetical protein	-
M1S41_RS19905 (M1S41_19905)	13904..14086	+	183	WP_000373384.1	hypothetical protein	-
M1S41_RS19910 (M1S41_19910)	14153..14851	+	699	WP_000873188.1	hypothetical protein	-
M1S41_RS19915 (M1S41_19915)	14990..15373	+	384	WP_000654347.1	hypothetical protein	-
M1S41_RS19920 (M1S41_19920)	15440..16198	+	759	WP_060853650.1	hypothetical protein	-
M1S41_RS19925 (M1S41_19925)	16250..16585	+	336	WP_000654055.1	hypothetical protein	-
M1S41_RS19930 (M1S41_19930)	17450..17764	+	315	WP_000708713.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..73209	73209

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (14-109)

Antitoxin

• HigA2-like, helix-turn-helix domain (12-88)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 13751.62 Da
• Isoelectric Point: 4.8212

>T243267 WP_000312250.1 NZ_CP096689:c13088-12729 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Nucleotide

• Length: 360 bp

>T243267 NZ_OW970486:c4849201-4848917 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCAGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11012.93 Da
• Isoelectric Point: 10.4856

>AT243267 WP_001096429.1 NZ_CP096689:c12729-12430 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Nucleotide

• Length: 300 bp

>AT243267 NZ_OW970486:c4849433-4849191 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA