Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3503941..3504635 Replicon chromosome
Accession NZ_CP096666
Organism Yersinia pestis EV76-CN

Toxin (Protein)


Gene name mqsR Uniprot ID A0A0E1NW62
Locus tag M0M60_RS15870 Protein ID WP_002214787.1
Coordinates 3503941..3504237 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q666X1
Locus tag M0M60_RS15875 Protein ID WP_002209924.1
Coordinates 3504237..3504635 (+) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M0M60_RS15840 (M0M60_15815) 3499063..3500580 + 1518 WP_002209930.1 lysine--tRNA ligase -
M0M60_RS15850 (M0M60_15825) 3501013..3502227 + 1215 WP_002209929.1 tyrosine-type recombinase/integrase -
M0M60_RS15855 (M0M60_15830) 3502309..3502494 - 186 WP_002209928.1 hypothetical protein -
M0M60_RS15860 (M0M60_15835) 3503092..3503352 + 261 WP_002214785.1 type II toxin-antitoxin system RelE/ParE family toxin -
M0M60_RS15865 (M0M60_15840) 3503415..3503777 + 363 WP_002209925.1 helix-turn-helix transcriptional regulator -
M0M60_RS15870 (M0M60_15845) 3503941..3504237 + 297 WP_002214787.1 type II toxin-antitoxin system MqsR family toxin Toxin
M0M60_RS15875 (M0M60_15850) 3504237..3504635 + 399 WP_002209924.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
M0M60_RS15880 (M0M60_15855) 3505035..3507330 - 2296 Protein_3083 primase-like DNA-binding domain-containing protein -
M0M60_RS15885 (M0M60_15860) 3507630..3507956 + 327 WP_002209922.1 type II toxin-antitoxin system RelE/ParE family toxin -
M0M60_RS15890 (M0M60_15865) 3507949..3508101 + 153 WP_002209921.1 hypothetical protein -
M0M60_RS15895 (M0M60_15870) 3508115..3508315 - 201 WP_002209920.1 AlpA family transcriptional regulator -
M0M60_RS15900 (M0M60_15875) 3508497..3508829 - 333 WP_002214791.1 hypothetical protein -
M0M60_RS15905 (M0M60_15880) 3508835..3509071 - 237 WP_002214792.1 hypothetical protein -
M0M60_RS15910 (M0M60_15885) 3509084..3509449 - 366 WP_002209919.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3496043..3522470 26427


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11319.12 Da        Isoelectric Point: 7.8810

>T243253 WP_002214787.1 NZ_CP096666:3503941-3504237 [Yersinia pestis EV76-CN]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLNVSFKEI

Download         Length: 297 bp

>T243253 NZ_OW970478:c4757521-4757237 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCAGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14657.17 Da        Isoelectric Point: 8.4923

>AT243253 WP_002209924.1 NZ_CP096666:3504237-3504635 [Yersinia pestis EV76-CN]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Download         Length: 399 bp

>AT243253 NZ_OW970478:c4757753-4757511 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1NW62

Antitoxin

Source ID Structure
AlphaFold DB Q666X1

References