Detailed information of TA system TA243163

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2623820..2624004
• Replicon: chromosome
• Accession: NZ_CP096540
• Organism: Staphylococcus aureus strain RIVM_M044329

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: M1F45_RS13330
• Protein ID: WP_000482647.1
• Coordinates: 2623897..2624004 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2623820..2623880 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1F45_RS13315 (M1F45_13300)	2619274..2619441	-	168	WP_001798790.1	hypothetical protein	-
M1F45_RS13320 (M1F45_13305)	2619672..2621405	-	1734	WP_000486511.1	ABC transporter ATP-binding protein	-
M1F45_RS13325 (M1F45_13310)	2621430..2623193	-	1764	WP_001064818.1	ABC transporter ATP-binding protein	-
-	2623820..2623880	+	61	-	-	Antitoxin
M1F45_RS13330 (M1F45_13315)	2623897..2624004	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
M1F45_RS13335 (M1F45_13320)	2624138..2624524	-	387	WP_000779355.1	flippase GtxA	-
M1F45_RS13340 (M1F45_13325)	2624791..2625933	+	1143	WP_001176859.1	glycerate kinase	-
M1F45_RS13345 (M1F45_13330)	2625993..2626652	+	660	WP_000831300.1	hypothetical protein	-
M1F45_RS13350 (M1F45_13335)	2626840..2628051	+	1212	WP_001191974.1	multidrug effflux MFS transporter	-
M1F45_RS13355 (M1F45_13340)	2628174..2628647	-	474	WP_000456489.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T243163 WP_000482647.1 NZ_CP096540:c2624004-2623897 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T243163 NZ_OW970366:c112974-112669 [Klebsiella pneumoniae]
ATGCAGTTCACCGTCTACGAATACACACGCGAGAGCCATTATCGTCTTTTTGTGGATGTGCAGAGCGACATTGTCGAGAC
GCCTGGGCGACGCATAGTGATCCCGTTGCTGGAATCGCACCACTTATCAGAAAAGGTTAATCAGCAGCTTTTCCCGGTGG
TTAGCGTCAATGGGAAAGAATACCGTGCCGTGACTTCCGAATTATCCGGAGTCTCTGTCAGTGTCATCGGCGACGCTGTG
GCCGATCTCAGCCATGAGGCAAATGCCATTAAAAATGCCCTGAACCTGATGTTCTGGGGCATTTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT243163 NZ_CP096540:2623820-2623880 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin