Detailed information of TA system TA243162

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2327951..2328214
• Replicon: chromosome
• Accession: NZ_CP096540
• Organism: Staphylococcus aureus strain RIVM_M044329

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: M1F45_RS11780
• Protein ID: WP_001802298.1
• Coordinates: 2328110..2328214 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	2327951..2328115 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1F45_RS11755 (M1F45_11740)	2324136..2324801	-	666	WP_001024099.1	SDR family oxidoreductase	-
M1F45_RS11760 (M1F45_11745)	2324953..2325273	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
M1F45_RS11765 (M1F45_11750)	2325275..2326255	+	981	WP_000019735.1	CDF family zinc efflux transporter CzrB	-
M1F45_RS11770 (M1F45_11755)	2326521..2327612	+	1092	WP_000495673.1	hypothetical protein	-
-	2327951..2328115	+	165	-	-	Antitoxin
M1F45_RS11780 (M1F45_11765)	2328110..2328214	-	105	WP_001802298.1	hypothetical protein	Toxin
M1F45_RS11785 (M1F45_11770)	2328894..2329052	+	159	WP_001792784.1	hypothetical protein	-
M1F45_RS11790 (M1F45_11775)	2329488..2329580	+	93	WP_000220902.1	hypothetical protein	-
M1F45_RS11795 (M1F45_11780)	2329710..2330567	-	858	WP_000370942.1	HAD family hydrolase	-
M1F45_RS11800 (M1F45_11785)	2330635..2331417	-	783	WP_000908191.1	ABC transporter ATP-binding protein	-
M1F45_RS11805 (M1F45_11790)	2331707..2332315	-	609	WP_000101714.1	TIR domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T243162 WP_001802298.1 NZ_CP096540:c2328214-2328110 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T243162 NZ_OW970365:c5244003-5243620 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Nucleotide

• Length: 165 bp

>AT243162 NZ_CP096540:2327951-2328115 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin