Detailed information of TA system TA243157

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-sprA1AS/-
• Location: 2184410..2184558
• Replicon: chromosome
• Accession: NZ_CP096540
• Organism: Staphylococcus aureus strain RIVM_M044329

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: -
• Locus tag: M1F45_RS11015
• Protein ID: WP_011276848.1
• Coordinates: 2184463..2184558 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	2184410..2184445 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1F45_RS10985 (M1F45_10970)	2180416..2180676	+	261	WP_031863946.1	persulfide-sensing transcriptional repressor CstR	-
M1F45_RS10990 (M1F45_10975)	2180676..2181431	+	756	WP_031863945.1	sulfite exporter TauE/SafE family protein	-
M1F45_RS10995 (M1F45_10980)	2181730..2182380	-	651	WP_031903407.1	NAD(P)-dependent oxidoreductase	-
M1F45_RS11000 (M1F45_10985)	2182565..2182972	-	408	Protein_2131	DsbA family protein	-
M1F45_RS11005 (M1F45_10990)	2183093..2183521	-	429	WP_031903408.1	Rrf2 family transcriptional regulator	-
M1F45_RS11010 (M1F45_10995)	2183635..2184126	-	492	Protein_2133	thymidylate synthase	-
-	2184410..2184445	-	36	-	-	Antitoxin
M1F45_RS11015 (M1F45_11000)	2184463..2184558	-	96	WP_011276848.1	type I toxin-antitoxin system Fst family toxin	Toxin
M1F45_RS11020 (M1F45_11005)	2184710..2185129	-	420	WP_224725316.1	DUF1700 domain-containing protein	-
M1F45_RS11025 (M1F45_11010)	2185494..2185676	-	183	WP_031903409.1	hypothetical protein	-
M1F45_RS11030 (M1F45_11015)	2187677..2188645	-	969	WP_031903411.1	replication initiator protein A	-
M1F45_RS11035 (M1F45_11020)	2188754..2189428	-	675	WP_216996543.1	IS6-like element IS257 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3623.38 Da
• Isoelectric Point: 9.5124

>T243157 WP_011276848.1 NZ_CP096540:c2184558-2184463 [Staphylococcus aureus]
MLEILVHITTTVISGCIIALFTHWLRNRKDK

Nucleotide

• Length: 96 bp

>T243157 NZ_OW970365:c2772586-2771264 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin

Nucleotide

• Length: 36 bp

>AT243157 NZ_CP096540:c2184445-2184410 [Staphylococcus aureus]
TACAAAAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin