Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | TMCS/- |
| Location | 1672705..1673284 | Replicon | chromosome |
| Accession | NZ_CP096540 | ||
| Organism | Staphylococcus aureus strain RIVM_M044329 | ||
Toxin (Protein)
| Gene name | MW1434 | Uniprot ID | A0A4P7P609 |
| Locus tag | M1F45_RS08295 | Protein ID | WP_001025401.1 |
| Coordinates | 1673039..1673284 (-) | Length | 82 a.a. |
Antitoxin (RNA)
| Gene name | MW1433 | ||
| Locus tag | - | ||
| Coordinates | 1672705..1673070 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M1F45_RS08240 (M1F45_08225) | 1667970..1668725 | - | 756 | WP_031794789.1 | DnaD domain protein | - |
| M1F45_RS08245 (M1F45_08230) | 1668718..1669392 | - | 675 | WP_031584874.1 | putative HNHc nuclease | - |
| M1F45_RS08250 (M1F45_08235) | 1669406..1669834 | - | 429 | WP_000934783.1 | single-stranded DNA-binding protein | - |
| M1F45_RS08255 (M1F45_08240) | 1669834..1670472 | - | 639 | WP_021285877.1 | ERF family protein | - |
| M1F45_RS08260 (M1F45_08245) | 1670472..1670951 | - | 480 | WP_000002513.1 | siphovirus Gp157 family protein | - |
| M1F45_RS08265 (M1F45_08250) | 1670944..1671180 | - | 237 | WP_000802315.1 | hypothetical protein | - |
| M1F45_RS08270 (M1F45_08255) | 1671188..1671448 | - | 261 | WP_000291075.1 | DUF1108 family protein | - |
| M1F45_RS08275 (M1F45_08260) | 1671540..1671701 | - | 162 | WP_000066011.1 | DUF1270 domain-containing protein | - |
| M1F45_RS08280 (M1F45_08265) | 1671714..1671923 | - | 210 | WP_000455728.1 | hypothetical protein | - |
| M1F45_RS08285 (M1F45_08270) | 1671936..1672649 | - | 714 | WP_058332268.1 | BRO family protein | - |
| M1F45_RS08290 (M1F45_08275) | 1672705..1673070 | + | 366 | WP_016170627.1 | hypothetical protein | Antitoxin |
| M1F45_RS08295 (M1F45_08280) | 1673039..1673284 | - | 246 | WP_001025401.1 | DUF2829 domain-containing protein | Toxin |
| M1F45_RS08300 (M1F45_08285) | 1673340..1673549 | + | 210 | WP_000642492.1 | hypothetical protein | - |
| M1F45_RS08305 (M1F45_08290) | 1673539..1673682 | - | 144 | WP_000939498.1 | hypothetical protein | - |
| M1F45_RS08310 (M1F45_08295) | 1673732..1673950 | - | 219 | WP_001001383.1 | hypothetical protein | - |
| M1F45_RS08315 (M1F45_08300) | 1673966..1674742 | - | 777 | WP_001148559.1 | phage antirepressor | - |
| M1F45_RS08320 (M1F45_08305) | 1674768..1674995 | - | 228 | WP_031903416.1 | hypothetical protein | - |
| M1F45_RS08325 (M1F45_08310) | 1675167..1675781 | + | 615 | WP_000801423.1 | XRE family transcriptional regulator | - |
| M1F45_RS08330 (M1F45_08315) | 1675797..1676717 | + | 921 | WP_031903415.1 | exonuclease domain-containing protein | - |
| M1F45_RS08335 (M1F45_08320) | 1676813..1676995 | + | 183 | WP_000705240.1 | hypothetical protein | - |
| M1F45_RS08340 (M1F45_08325) | 1677031..1677177 | + | 147 | WP_001013104.1 | hypothetical protein | - |
| M1F45_RS08345 (M1F45_08330) | 1677174..1677788 | - | 615 | WP_114161228.1 | ATPase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1634456..1691875 | 57419 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 82 a.a. Molecular weight: 9468.72 Da Isoelectric Point: 5.7783
>T243153 WP_001025401.1 NZ_CP096540:c1673284-1673039 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F
Download Length: 246 bp
>T243153 NZ_OW970365:835736-836146 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA
Antitoxin
Download Length: 366 bp
>AT243153 NZ_CP096540:1672705-1673070 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTACGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTACGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
