Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 1663046..1663460 Replicon chromosome
Accession NZ_CP096540
Organism Staphylococcus aureus strain RIVM_M044329

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag M1F45_RS08175 Protein ID WP_031267622.1
Coordinates 1663209..1663460 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M1F45_RS08170 Protein ID WP_000028424.1
Coordinates 1663046..1663219 (-) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1F45_RS08115 (M1F45_08100) 1658168..1658482 - 315 WP_000160683.1 HNH endonuclease -
M1F45_RS08120 (M1F45_08105) 1658639..1659076 - 438 WP_000513703.1 transcriptional regulator -
M1F45_RS08125 (M1F45_08110) 1659089..1660456 - 1368 WP_078100831.1 DEAD/DEAH box helicase -
M1F45_RS08130 (M1F45_08115) 1660437..1660727 - 291 WP_000665203.1 VRR-NUC domain-containing protein -
M1F45_RS08135 (M1F45_08120) 1660861..1660965 + 105 WP_015978074.1 hypothetical protein -
M1F45_RS08140 (M1F45_08125) 1661068..1661532 - 465 Protein_1599 hypothetical protein -
M1F45_RS08145 (M1F45_08130) 1661703..1661903 - 201 WP_000265258.1 DUF1514 family protein -
M1F45_RS08150 (M1F45_08135) 1661971..1662123 - 153 WP_031838395.1 transcriptional regulator -
M1F45_RS08155 (M1F45_08140) 1662120..1662326 - 207 WP_031920873.1 DUF1381 domain-containing protein -
M1F45_RS08160 (M1F45_08145) 1662363..1662869 - 507 WP_001061842.1 dUTPase -
M1F45_RS08165 (M1F45_08150) 1662884..1663045 - 162 WP_000889684.1 hypothetical protein -
M1F45_RS08170 (M1F45_08155) 1663046..1663219 - 174 WP_000028424.1 hypothetical protein Antitoxin
M1F45_RS08175 (M1F45_08160) 1663209..1663460 - 252 WP_031267622.1 DUF1024 family protein Toxin
M1F45_RS08180 (M1F45_08165) 1663453..1663761 - 309 WP_000144708.1 hypothetical protein -
M1F45_RS08185 (M1F45_08170) 1663758..1664105 - 348 WP_000979209.1 YopX family protein -
M1F45_RS08190 (M1F45_08175) 1664102..1664503 - 402 WP_031796932.1 hypothetical protein -
M1F45_RS08195 (M1F45_08180) 1664506..1664712 - 207 WP_000693987.1 hypothetical protein -
M1F45_RS08200 (M1F45_08185) 1664726..1664974 - 249 WP_031796934.1 phi PVL orf 51-like protein -
M1F45_RS08205 (M1F45_08190) 1664975..1665334 - 360 WP_031838377.1 SA1788 family PVL leukocidin-associated protein -
M1F45_RS08210 (M1F45_08195) 1665335..1665520 - 186 WP_031838378.1 DUF3113 family protein -
M1F45_RS08215 (M1F45_08200) 1665525..1665929 - 405 WP_000049798.1 DUF1064 domain-containing protein -
M1F45_RS08220 (M1F45_08205) 1665940..1666161 - 222 WP_001123688.1 DUF3269 family protein -
M1F45_RS08225 (M1F45_08210) 1666164..1666379 - 216 WP_021285875.1 hypothetical protein -
M1F45_RS08230 (M1F45_08215) 1666376..1667617 - 1242 WP_103147420.1 DnaB helicase C-terminal domain-containing protein -
M1F45_RS08235 (M1F45_08220) 1667614..1667970 - 357 WP_031794788.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1634456..1691875 57419


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9419.35 Da        Isoelectric Point: 3.9476

>T243152 WP_031267622.1 NZ_CP096540:c1663460-1663209 [Staphylococcus aureus]
MNNREKIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGIELDEAVGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T243152 NZ_OW970365:358315-358662 [Klebsiella pneumoniae]
ATGTGGGATGTGGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCTTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATAAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT243152 WP_000028424.1 NZ_CP096540:c1663219-1663046 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT243152 NZ_OW970365:358662-358961 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGACTGATAACGACCCTCGGCTTTCGACCCTAAAAAGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References