Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 914756..915170 Replicon chromosome
Accession NZ_CP096540
Organism Staphylococcus aureus strain RIVM_M044329

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag M1F45_RS04555 Protein ID WP_031267622.1
Coordinates 914756..915007 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M1F45_RS04560 Protein ID WP_000028424.1
Coordinates 914997..915170 (+) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1F45_RS04495 (M1F45_04485) 910084..911325 + 1242 WP_001106166.1 DnaB helicase C-terminal domain-containing protein -
M1F45_RS04500 (M1F45_04490) 911322..911537 + 216 WP_021285875.1 hypothetical protein -
M1F45_RS04505 (M1F45_04495) 911540..911761 + 222 WP_001123688.1 DUF3269 family protein -
M1F45_RS04510 (M1F45_04500) 911771..912178 + 408 WP_021285874.1 RusA family crossover junction endodeoxyribonuclease -
M1F45_RS04515 (M1F45_04505) 912178..912363 + 186 WP_021285873.1 DUF3113 family protein -
M1F45_RS04520 (M1F45_04510) 912364..912981 + 618 WP_021285872.1 SA1788 family PVL leukocidin-associated protein -
M1F45_RS04525 (M1F45_04515) 912981..913235 + 255 WP_021285871.1 DUF3310 domain-containing protein -
M1F45_RS04530 (M1F45_04520) 913235..913483 + 249 WP_078069534.1 SAV1978 family virulence-associated passenger protein -
M1F45_RS04535 (M1F45_04525) 913498..913704 + 207 WP_021285869.1 hypothetical protein -
M1F45_RS04540 (M1F45_04530) 913707..914114 + 408 WP_000695770.1 hypothetical protein -
M1F45_RS04545 (M1F45_04535) 914111..914458 + 348 WP_000979209.1 YopX family protein -
M1F45_RS04550 (M1F45_04540) 914455..914763 + 309 WP_000144708.1 hypothetical protein -
M1F45_RS04555 (M1F45_04545) 914756..915007 + 252 WP_031267622.1 DUF1024 family protein Toxin
M1F45_RS04560 (M1F45_04550) 914997..915170 + 174 WP_000028424.1 hypothetical protein Antitoxin
M1F45_RS04565 (M1F45_04555) 915171..915332 + 162 WP_000889684.1 hypothetical protein -
M1F45_RS04570 (M1F45_04560) 915347..915853 + 507 WP_001061842.1 dUTPase -
M1F45_RS04575 (M1F45_04565) 915890..916096 + 207 WP_021285914.1 DUF1381 domain-containing protein -
M1F45_RS04580 (M1F45_04570) 916093..916296 + 204 WP_000141180.1 hypothetical protein -
M1F45_RS04585 (M1F45_04575) 916289..916525 + 237 WP_000608281.1 hypothetical protein -
M1F45_RS04590 (M1F45_04580) 916515..916904 + 390 WP_169538641.1 hypothetical protein -
M1F45_RS04595 (M1F45_04585) 916901..917074 + 174 WP_000595258.1 transcriptional activator RinB -
M1F45_RS04600 (M1F45_04590) 917075..917476 + 402 WP_000286968.1 hypothetical protein -
M1F45_RS04605 (M1F45_04595) 917824..918204 + 381 WP_031838201.1 DNA-binding protein -
M1F45_RS04610 (M1F45_04600) 918188..919453 + 1266 WP_031838202.1 PBSX family phage terminase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 898299..949102 50803


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9419.35 Da        Isoelectric Point: 3.9476

>T243150 WP_031267622.1 NZ_CP096540:914756-915007 [Staphylococcus aureus]
MNNREKIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGIELDEAVGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T243150 NZ_OW970359:c30991-30575 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACCAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGTGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCGTGGGACCGGGCT
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGCACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGACACGCCATCGCGGCGGGCGCCATCCTGGTGACGAATAATACAAGAGAGTTTGCGCGGGTCCCGGGCCTGGTGCTGG
AAGACTGGGTGAATTAA

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT243150 WP_000028424.1 NZ_CP096540:914997-915170 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT243150 NZ_OW970359:c31218-30988 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGTGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAACGCGAGGATGTGGTCAGCGACGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References