Detailed information of TA system TA243147

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 359815..360394
• Replicon: chromosome
• Accession: NZ_CP096540
• Organism: Staphylococcus aureus strain RIVM_M044329

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: M1F45_RS01615
• Protein ID: WP_001025401.1
• Coordinates: 359815..360060 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	360029..360394 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1F45_RS01570 (M1F45_01565)	355833..356447	+	615	WP_000191466.1	hypothetical protein	-
M1F45_RS01575 (M1F45_01570)	356444..356590	-	147	WP_074370993.1	hypothetical protein	-
M1F45_RS01580 (M1F45_01575)	356820..357404	-	585	WP_000825948.1	hypothetical protein	-
M1F45_RS01585 (M1F45_01580)	357422..357883	-	462	WP_000525004.1	hypothetical protein	-
M1F45_RS01590 (M1F45_01585)	357896..358210	-	315	WP_000333630.1	helix-turn-helix transcriptional regulator	-
M1F45_RS01595 (M1F45_01590)	358362..358598	+	237	WP_001121027.1	helix-turn-helix transcriptional regulator	-
M1F45_RS01600 (M1F45_01595)	358612..359388	+	777	WP_001148544.1	Rha family transcriptional regulator	-
M1F45_RS01605 (M1F45_01600)	359417..359560	+	144	WP_031797335.1	hypothetical protein	-
M1F45_RS01610 (M1F45_01605)	359550..359759	-	210	WP_000642492.1	hypothetical protein	-
M1F45_RS01615 (M1F45_01610)	359815..360060	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
M1F45_RS01620 (M1F45_01615)	360029..360394	-	366	WP_001128433.1	hypothetical protein	Antitoxin
M1F45_RS01625 (M1F45_01620)	360449..360664	+	216	WP_001097552.1	hypothetical protein	-
M1F45_RS01630 (M1F45_01625)	360689..360952	+	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
M1F45_RS01635 (M1F45_01630)	360965..361135	+	171	WP_031920869.1	DUF1270 domain-containing protein	-
M1F45_RS01640 (M1F45_01635)	361116..361454	+	339	WP_224727996.1	XRE family transcriptional regulator	-
M1F45_RS01645 (M1F45_01640)	361519..361821	+	303	WP_031838380.1	DUF2482 family protein	-
M1F45_RS01650 (M1F45_01645)	361826..362086	+	261	WP_000291481.1	DUF1108 family protein	-
M1F45_RS01655 (M1F45_01650)	362099..362635	+	537	WP_000999048.1	host-nuclease inhibitor Gam family protein	-
M1F45_RS01660 (M1F45_01655)	362636..363415	+	780	WP_000137071.1	ATP-binding protein	-
M1F45_RS01665 (M1F45_01660)	363445..363999	+	555	WP_000704713.1	single-stranded DNA-binding protein	-
M1F45_RS01670 (M1F45_01665)	364012..364683	+	672	WP_031838379.1	putative HNHc nuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	354502..401166	46664

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T243147 WP_001025401.1 NZ_CP096540:359815-360060 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T243147 NZ_OW970357:c4929153-4928278 [Klebsiella pneumoniae]
ATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATTTGCGCTGAAAGGTGGCACTGCCATCAATCTCTTTATCCGCGA
TTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGGTGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGG
ATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAGGCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAG
ATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAAGATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACC
ACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTTTTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCT
ACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCATCCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAG
GAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTATTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCC
TCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAATTCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGA
CAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCCTGTATCACACAACAGGATGTCGATTTTTTACTGTCATTTAAA
CGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCGTATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATAT
TCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAGATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT243147 NZ_CP096540:c360394-360029 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin