243144

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2497128..2497312 Replicon chromosome
Accession NZ_CP096539
Organism Staphylococcus aureus strain RIVM_M047065

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag M1F46_RS12405 Protein ID WP_000482647.1
Coordinates 2497205..2497312 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2497128..2497188 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1F46_RS12390 (M1F46_12385) 2492582..2492749 - 168 WP_001798790.1 hypothetical protein -
M1F46_RS12395 (M1F46_12390) 2492980..2494713 - 1734 WP_000486511.1 ABC transporter ATP-binding protein -
M1F46_RS12400 (M1F46_12395) 2494738..2496501 - 1764 WP_001064818.1 ABC transporter ATP-binding protein -
- 2497128..2497188 + 61 - - Antitoxin
M1F46_RS12405 (M1F46_12400) 2497205..2497312 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
M1F46_RS12410 (M1F46_12405) 2497446..2497832 - 387 WP_000779355.1 flippase GtxA -
M1F46_RS12415 (M1F46_12410) 2498099..2499241 + 1143 WP_001176859.1 glycerate kinase -
M1F46_RS12420 (M1F46_12415) 2499301..2499960 + 660 WP_000831300.1 hypothetical protein -
M1F46_RS12425 (M1F46_12420) 2500148..2501359 + 1212 WP_001191974.1 multidrug effflux MFS transporter -
M1F46_RS12430 (M1F46_12425) 2501482..2501955 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T243144 WP_000482647.1 NZ_CP096539:c2497312-2497205 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T243144 NZ_OW970357:4037315-4037533 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 61 bp

>AT243144 NZ_CP096539:2497128-2497188 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References