Detailed information of TA system TA243143

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprG3-SprA2AS/-
• Location: 2201400..2201598
• Replicon: chromosome
• Accession: NZ_CP096539
• Organism: Staphylococcus aureus strain RIVM_M047065

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: M1F46_RS10855
• Protein ID: WP_001802298.1
• Coordinates: 2201494..2201598 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2201400..2201438 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1F46_RS10830 (M1F46_10825)	2197520..2198185	-	666	WP_001024099.1	SDR family oxidoreductase	-
M1F46_RS10835 (M1F46_10830)	2198337..2198657	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
M1F46_RS10840 (M1F46_10835)	2198659..2199639	+	981	WP_000019735.1	CDF family zinc efflux transporter CzrB	-
M1F46_RS10845 (M1F46_10840)	2199905..2200996	+	1092	WP_000495673.1	hypothetical protein	-
M1F46_RS10850 (M1F46_10845)	2201380..2201454	+	75	Protein_2096	hypothetical protein	-
-	2201400..2201438	+	39	-	-	Antitoxin
M1F46_RS10855 (M1F46_10850)	2201494..2201598	-	105	WP_001802298.1	hypothetical protein	Toxin
M1F46_RS10860 (M1F46_10855)	2202278..2202436	+	159	WP_001792784.1	hypothetical protein	-
M1F46_RS10865 (M1F46_10860)	2202872..2202964	+	93	WP_000220902.1	hypothetical protein	-
M1F46_RS10870 (M1F46_10865)	2203094..2203951	-	858	WP_000370942.1	HAD family hydrolase	-
M1F46_RS10875 (M1F46_10870)	2204019..2204801	-	783	WP_000908191.1	ABC transporter ATP-binding protein	-
M1F46_RS10880 (M1F46_10875)	2205091..2205699	-	609	WP_000101714.1	TIR domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T243143 WP_001802298.1 NZ_CP096539:c2201598-2201494 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T243143 NZ_OW970357:c2769527-2768205 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
CAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACCCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin

Nucleotide

• Length: 39 bp

>AT243143 NZ_CP096539:2201400-2201438 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin