Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | TMCS/- |
| Location | 1589116..1589695 | Replicon | chromosome |
| Accession | NZ_CP096539 | ||
| Organism | Staphylococcus aureus strain RIVM_M047065 | ||
Toxin (Protein)
| Gene name | MW1434 | Uniprot ID | A0A4P7P609 |
| Locus tag | M1F46_RS07625 | Protein ID | WP_001025401.1 |
| Coordinates | 1589450..1589695 (-) | Length | 82 a.a. |
Antitoxin (RNA)
| Gene name | MW1433 | ||
| Locus tag | - | ||
| Coordinates | 1589116..1589481 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M1F46_RS07570 (M1F46_07560) | 1584827..1585498 | - | 672 | WP_031838379.1 | putative HNHc nuclease | - |
| M1F46_RS07575 (M1F46_07565) | 1585511..1586065 | - | 555 | WP_000704713.1 | single-stranded DNA-binding protein | - |
| M1F46_RS07580 (M1F46_07570) | 1586095..1586874 | - | 780 | WP_000137071.1 | ATP-binding protein | - |
| M1F46_RS07585 (M1F46_07575) | 1586875..1587411 | - | 537 | WP_000999048.1 | host-nuclease inhibitor Gam family protein | - |
| M1F46_RS07590 (M1F46_07580) | 1587424..1587684 | - | 261 | WP_000291481.1 | DUF1108 family protein | - |
| M1F46_RS07595 (M1F46_07585) | 1587689..1587991 | - | 303 | WP_031838380.1 | DUF2482 family protein | - |
| M1F46_RS07600 (M1F46_07590) | 1588056..1588370 | - | 315 | WP_031838381.1 | hypothetical protein | - |
| M1F46_RS07605 (M1F46_07595) | 1588375..1588545 | - | 171 | WP_031838382.1 | DUF1270 domain-containing protein | - |
| M1F46_RS07610 (M1F46_07600) | 1588558..1588821 | - | 264 | WP_001124160.1 | helix-turn-helix domain-containing protein | - |
| M1F46_RS07615 (M1F46_07605) | 1588846..1589061 | - | 216 | WP_001097552.1 | hypothetical protein | - |
| M1F46_RS07620 (M1F46_07610) | 1589116..1589481 | + | 366 | WP_016170627.1 | hypothetical protein | Antitoxin |
| M1F46_RS07625 (M1F46_07615) | 1589450..1589695 | - | 246 | WP_001025401.1 | DUF2829 domain-containing protein | Toxin |
| M1F46_RS07630 (M1F46_07620) | 1589751..1589960 | + | 210 | WP_000642492.1 | hypothetical protein | - |
| M1F46_RS07635 (M1F46_07625) | 1589950..1590093 | - | 144 | WP_000939498.1 | hypothetical protein | - |
| M1F46_RS07640 (M1F46_07630) | 1590164..1590376 | + | 213 | WP_000362644.1 | hypothetical protein | - |
| M1F46_RS07645 (M1F46_07635) | 1590417..1590566 | - | 150 | WP_000771849.1 | hypothetical protein | - |
| M1F46_RS07650 (M1F46_07640) | 1590581..1591024 | - | 444 | WP_000435362.1 | hypothetical protein | - |
| M1F46_RS07655 (M1F46_07645) | 1591006..1591284 | - | 279 | WP_267441881.1 | helix-turn-helix transcriptional regulator | - |
| M1F46_RS07660 (M1F46_07650) | 1591448..1591771 | + | 324 | WP_001260487.1 | helix-turn-helix transcriptional regulator | - |
| M1F46_RS07665 (M1F46_07655) | 1591784..1592245 | + | 462 | WP_000525004.1 | hypothetical protein | - |
| M1F46_RS07670 (M1F46_07660) | 1592263..1592847 | + | 585 | WP_000825948.1 | hypothetical protein | - |
| M1F46_RS07675 (M1F46_07665) | 1593077..1593223 | + | 147 | WP_001795334.1 | hypothetical protein | - |
| M1F46_RS07680 (M1F46_07670) | 1593220..1593834 | - | 615 | WP_000191464.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | gnd | 1550170..1617753 | 67583 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 82 a.a. Molecular weight: 9468.72 Da Isoelectric Point: 5.7783
>T243136 WP_001025401.1 NZ_CP096539:c1589695-1589450 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F
Download Length: 246 bp
>T243136 NZ_OW970318:72789-73076 [Pantoea agglomerans]
GTGAGTTGTACCGTCAAATTCAGGGAAGAGGCATTTAAAGAATGGCAGAAGCTGGACAAATCTCTCCAGCAGCAGTTTGC
CAAAAAACTGAAGAAATGTTGTGACAATCCCCATATTCCTTCTGCCAGACTACGAGGGATTAAAGACTGCTATAAAATCA
AACTCAGAGCGTCCGGGTTTCGCCTGGTTTATCAGGTAATAGACGATCAACTGGTGATTGCCGTTGTTGCTGTGGGTAAA
CGCGAGCGCAGCGATATTTATCATCTTGCCAGTGAAAGGATGCGGTAG
GTGAGTTGTACCGTCAAATTCAGGGAAGAGGCATTTAAAGAATGGCAGAAGCTGGACAAATCTCTCCAGCAGCAGTTTGC
CAAAAAACTGAAGAAATGTTGTGACAATCCCCATATTCCTTCTGCCAGACTACGAGGGATTAAAGACTGCTATAAAATCA
AACTCAGAGCGTCCGGGTTTCGCCTGGTTTATCAGGTAATAGACGATCAACTGGTGATTGCCGTTGTTGCTGTGGGTAAA
CGCGAGCGCAGCGATATTTATCATCTTGCCAGTGAAAGGATGCGGTAG
Antitoxin
Download Length: 366 bp
>AT243136 NZ_CP096539:1589116-1589481 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTACGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTACGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
