Detailed information of TA system TA243133

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2535514..2535698
• Replicon: chromosome
• Accession: NZ_CP096535
• Organism: Staphylococcus aureus strain RIVM_M047916

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: M1F47_RS12715
• Protein ID: WP_000482647.1
• Coordinates: 2535591..2535698 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2535514..2535574 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1F47_RS12700 (M1F47_12685)	2530968..2531135	-	168	WP_001798790.1	hypothetical protein	-
M1F47_RS12705 (M1F47_12690)	2531366..2533099	-	1734	WP_000486511.1	ABC transporter ATP-binding protein	-
M1F47_RS12710 (M1F47_12695)	2533124..2534887	-	1764	WP_001064818.1	ABC transporter ATP-binding protein	-
-	2535514..2535574	+	61	-	-	Antitoxin
M1F47_RS12715 (M1F47_12700)	2535591..2535698	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
M1F47_RS12720 (M1F47_12705)	2535832..2536218	-	387	WP_000779355.1	flippase GtxA	-
M1F47_RS12725 (M1F47_12710)	2536485..2537627	+	1143	WP_001176859.1	glycerate kinase	-
M1F47_RS12730 (M1F47_12715)	2537687..2538346	+	660	WP_000831300.1	hypothetical protein	-
M1F47_RS12735 (M1F47_12720)	2538534..2539745	+	1212	WP_001191974.1	multidrug effflux MFS transporter	-
M1F47_RS12740 (M1F47_12725)	2539868..2540341	-	474	WP_000456489.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T243133 WP_000482647.1 NZ_CP096535:c2535698-2535591 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T243133 NZ_OW970316:190314-190625 [Pantoea agglomerans]
ATGCATATCATCTCAAGAGGGCCGTTCAGGGAAGCGGCAATAATTTATCCAAATCATGCTTCCGCACTGGATGCGGCTTA
TCTGGTCCTCAGGGACGAAAACTTTGCCACGCCAGATGCGCTGAAAATTCGCTTTCAGAGCCTTGACCGCATGAAGTACC
GGGAAAAGTGGTGGGTAATCGATGTGGGCGGAAACAGCCTGAGGATCATGTTCTATGCTGACTTTGATCGAGGCAAAATT
TTTATCAAGCACATCGTGACGCATGCGGAATATGACAAGCTGGTGAAGAAGTACCGGGAGAGTAAAGAATGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT243133 NZ_CP096535:2535514-2535574 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin