Detailed information of TA system TA243132

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprG3-SprA2AS/-
• Location: 2239726..2239924
• Replicon: chromosome
• Accession: NZ_CP096535
• Organism: Staphylococcus aureus strain RIVM_M047916

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: M1F47_RS11165
• Protein ID: WP_001802298.1
• Coordinates: 2239820..2239924 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2239726..2239764 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1F47_RS11140 (M1F47_11125)	2235846..2236511	-	666	WP_001024099.1	SDR family oxidoreductase	-
M1F47_RS11145 (M1F47_11130)	2236663..2236983	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
M1F47_RS11150 (M1F47_11135)	2236985..2237965	+	981	WP_000019735.1	CDF family zinc efflux transporter CzrB	-
M1F47_RS11155 (M1F47_11140)	2238231..2239322	+	1092	WP_000495673.1	hypothetical protein	-
M1F47_RS11160 (M1F47_11145)	2239706..2239780	+	75	Protein_2158	hypothetical protein	-
-	2239726..2239764	+	39	-	-	Antitoxin
M1F47_RS11165 (M1F47_11150)	2239820..2239924	-	105	WP_001802298.1	hypothetical protein	Toxin
M1F47_RS11170 (M1F47_11155)	2240604..2240762	+	159	WP_001792784.1	hypothetical protein	-
M1F47_RS11175 (M1F47_11160)	2241198..2241290	+	93	WP_000220902.1	hypothetical protein	-
M1F47_RS11180 (M1F47_11165)	2241420..2242277	-	858	WP_000370942.1	HAD family hydrolase	-
M1F47_RS11185 (M1F47_11170)	2242345..2243127	-	783	WP_000908191.1	ABC transporter ATP-binding protein	-
M1F47_RS11190 (M1F47_11175)	2243417..2244025	-	609	WP_000101714.1	TIR domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T243132 WP_001802298.1 NZ_CP096535:c2239924-2239820 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T243132 NZ_OW970315:c4117766-4117413 [Pantoea agglomerans]
ATGTGGGATGTGGATACAACCAAAAGATTTGATGAGTGGTTTAAGGCTCAGAGTGAGGAACTGAAGGAGGATATGCTCGC
CGCGATAGTTATCCTGTCTGAGTATGGGCCGCATTTAGCGAGGCCGTTTGCTGATACTGTAGACGGCTCTGATTTTCCGA
ATATGAAAGAATTAAGAGTGCAGCATCAAGGCAAACCGATACGGGCCTTCTTTGCTTTTGATCCTTCTCGCCGCGGCATT
GTGTTGTGTGCAGGCGATAAAACCGGGGTTAAGGAAAAGAAATTCTATAAAGACATGATCAAATTGGCAGATGCTGAATT
CCGCAAATATTTGAATGGAGGGGATAATGGCTAA

Antitoxin

Nucleotide

• Length: 39 bp

>AT243132 NZ_CP096535:2239726-2239764 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin