Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) TMCS/-
Location 1586028..1586607 Replicon chromosome
Accession NZ_CP096535
Organism Staphylococcus aureus strain RIVM_M047916

Toxin (Protein)


Gene name MW1434 Uniprot ID A0A4P7P609
Locus tag M1F47_RS07620 Protein ID WP_001025401.1
Coordinates 1586362..1586607 (-) Length 82 a.a.

Antitoxin (RNA)


Gene name MW1433
Locus tag -
Coordinates 1586028..1586393 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1F47_RS07565 (M1F47_07555) 1581739..1582410 - 672 WP_031838379.1 putative HNHc nuclease -
M1F47_RS07570 (M1F47_07560) 1582423..1582977 - 555 WP_000704713.1 single-stranded DNA-binding protein -
M1F47_RS07575 (M1F47_07565) 1583007..1583786 - 780 WP_000137071.1 ATP-binding protein -
M1F47_RS07580 (M1F47_07570) 1583787..1584323 - 537 WP_000999048.1 host-nuclease inhibitor Gam family protein -
M1F47_RS07585 (M1F47_07575) 1584336..1584596 - 261 WP_000291481.1 DUF1108 family protein -
M1F47_RS07590 (M1F47_07580) 1584601..1584903 - 303 WP_031838380.1 DUF2482 family protein -
M1F47_RS07595 (M1F47_07585) 1584968..1585282 - 315 WP_031838381.1 hypothetical protein -
M1F47_RS07600 (M1F47_07590) 1585287..1585457 - 171 WP_031838382.1 DUF1270 domain-containing protein -
M1F47_RS07605 (M1F47_07595) 1585470..1585733 - 264 WP_001124160.1 helix-turn-helix domain-containing protein -
M1F47_RS07610 (M1F47_07600) 1585758..1585973 - 216 WP_001097552.1 hypothetical protein -
M1F47_RS07615 (M1F47_07605) 1586028..1586393 + 366 WP_016170627.1 hypothetical protein Antitoxin
M1F47_RS07620 (M1F47_07610) 1586362..1586607 - 246 WP_001025401.1 DUF2829 domain-containing protein Toxin
M1F47_RS07625 (M1F47_07615) 1586663..1586872 + 210 WP_000642492.1 hypothetical protein -
M1F47_RS07630 (M1F47_07620) 1586862..1587005 - 144 WP_000939498.1 hypothetical protein -
M1F47_RS07635 (M1F47_07625) 1587076..1587288 + 213 WP_000362644.1 hypothetical protein -
M1F47_RS07640 (M1F47_07630) 1587329..1587478 - 150 WP_000771849.1 hypothetical protein -
M1F47_RS07645 (M1F47_07635) 1587493..1587936 - 444 WP_000435362.1 hypothetical protein -
M1F47_RS07650 (M1F47_07640) 1587962..1588738 - 777 WP_031796638.1 Rha family transcriptional regulator -
M1F47_RS07655 (M1F47_07645) 1588761..1588988 - 228 WP_015978369.1 helix-turn-helix transcriptional regulator -
M1F47_RS07660 (M1F47_07650) 1589142..1589771 + 630 WP_029549401.1 XRE family transcriptional regulator -
M1F47_RS07665 (M1F47_07655) 1589828..1590424 + 597 WP_031796639.1 hypothetical protein -
M1F47_RS07670 (M1F47_07660) 1590654..1590800 + 147 WP_078067907.1 hypothetical protein -
M1F47_RS07675 (M1F47_07665) 1590797..1591411 - 615 WP_000191459.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1543475..1610373 66898


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF2829

(2-69)


Sequences

Toxin        


Download         Length: 82 a.a.        Molecular weight: 9468.72 Da        Isoelectric Point: 5.7783

>T243126 WP_001025401.1 NZ_CP096535:c1586607-1586362 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Download         Length: 246 bp

>T243126 NZ_OW969912:c5045660-5044743 [Klebsiella variicola]
ATGGATATACAGGCGCCCTATTATCGGCAGGTTGCTCTGTTAATGCAGGTTTTACCCTATGTTGCCGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACGGCAATCAATCTCTTTATCCGTGATTTCCCACGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAACGATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCTCTAATCTGCAACAACAG
GCAGGTATGAACGCTGTATTACAAGCTAATCGTTCCGATGAGATGCGTGTCGTTGTTACTACCGATAGCGCACAAATAAA
GATAGAGGTCTCACCGGTCGCACGGGGAACATTATATCCACCACAGGAGCGAGAGGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCGGTGGTTTCGTTGCCCGATCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGATGTGAAATTACTTCTTGATGCGCAGGAGCTTAACCGTCCCATTTTCAATGGGTTTATCGCGTA
TTTACTTAGCCATAATCGGCCTCTGGCTGAAGTGCTTAGTCCTCGCTGGAAAGATATTGCTGAACCCTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCTACAGGATGATTGATGCGTTAAAATCC
TGTTTCACGCAACAGGATATCGATTTTTTGCTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAACACG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCGTTAG
ATAAACTGGAAAAGGTGTTGGCCGAGTGGCGCAGTTAG

Antitoxin


Download         Length: 366 bp

>AT243126 NZ_CP096535:1586028-1586393 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTACGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7P609

Antitoxin

Download structure file

References