Detailed information of TA system TA243123

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2584117..2584301
• Replicon: chromosome
• Accession: NZ_CP096532
• Organism: Staphylococcus aureus strain RIVM_M083782

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: M1F48_RS13030
• Protein ID: WP_000482647.1
• Coordinates: 2584194..2584301 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2584117..2584177 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1F48_RS13015 (M1F48_12990)	2579571..2579738	-	168	WP_001798790.1	hypothetical protein	-
M1F48_RS13020 (M1F48_12995)	2579969..2581702	-	1734	WP_000486511.1	ABC transporter ATP-binding protein	-
M1F48_RS13025 (M1F48_13000)	2581727..2583490	-	1764	WP_001064818.1	ABC transporter ATP-binding protein	-
-	2584117..2584177	+	61	-	-	Antitoxin
M1F48_RS13030 (M1F48_13005)	2584194..2584301	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
M1F48_RS13035 (M1F48_13010)	2584435..2584821	-	387	WP_000779355.1	flippase GtxA	-
M1F48_RS13040 (M1F48_13015)	2585088..2586230	+	1143	WP_001176859.1	glycerate kinase	-
M1F48_RS13045 (M1F48_13020)	2586290..2586949	+	660	WP_000831300.1	hypothetical protein	-
M1F48_RS13050 (M1F48_13025)	2587137..2588348	+	1212	WP_001191974.1	multidrug effflux MFS transporter	-
M1F48_RS13055 (M1F48_13030)	2588471..2588944	-	474	WP_000456489.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T243123 WP_000482647.1 NZ_CP096532:c2584301-2584194 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T243123 NZ_OW969912:c4013045-4012728 [Klebsiella variicola]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAAATAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT243123 NZ_CP096532:2584117-2584177 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin