Detailed information of TA system TA024312

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 1872029..1872400
• Replicon: chromosome
• Accession: NC_013361
• Organism: Escherichia coli O26:H11 str. 11368

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: A0A0D6ZRD3
• Locus tag: ECO26_RS10060
• Protein ID: WP_001443846.1
• Coordinates: 1872251..1872400 (-)
• Length: 50 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	1872029..1872207 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ECO26_RS10035	1867984..1869357	+	1374	WP_000123745.1	ATP-dependent RNA helicase DbpA	-
ECO26_RS10040	1869486..1870421	-	936	WP_001157407.1	tRNA 2-thiocytidine(32) synthetase TtcA	-
ECO26_RS31770	1870473..1871708	-	1236	WP_000040851.1	site-specific integrase	-
ECO26_RS10050	1871710..1871925	-	216	WP_000079604.1	excisionase XisR	-
ECO26_RS10055	1872025..1872213	-	189	WP_001302840.1	DUF1187 family protein	-
-	1872029..1872207	+	179	NuclAT_0	-	Antitoxin
-	1872029..1872207	+	179	NuclAT_0	-	Antitoxin
-	1872029..1872207	+	179	NuclAT_0	-	Antitoxin
-	1872029..1872207	+	179	NuclAT_0	-	Antitoxin
ECO26_RS10060	1872251..1872400	-	150	WP_001443846.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
ECO26_RS10065	1872456..1873265	-	810	WP_000166313.1	recombination protein RecT	-
ECO26_RS10070	1873258..1875858	-	2601	WP_000105151.1	exodeoxyribonuclease VIII	-
ECO26_RS10075	1875960..1876235	-	276	WP_000632297.1	protein RacC	-
ECO26_RS10080	1876310..1876480	-	171	WP_001352098.1	conserved protein, Rac prophage	-
ECO26_RS10085	1876480..1876701	-	222	WP_000560223.1	killing protein KilR	-
ECO26_RS10090	1877122..1877274	-	153	WP_001427316.1	DUF1391 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1870473..1915148	44675

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-48)

Sequences

Toxin

Protein

• Length: 50 a.a.
• Molecular weight: 5383.12 Da
• Isoelectric Point: 8.3398

>T24312 WP_001443846.1 NC_013361:c1872400-1872251 [Escherichia coli O26:H11 str. 11368]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALER

Nucleotide

• Length: 150 bp

>T24312 NC_013361:c1872400-1872251 [Escherichia coli O26:H11 str. 11368]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAACGATGA

Antitoxin

Nucleotide

• Length: 179 bp

>AT24312 NC_013361:1872029-1872207 [Escherichia coli O26:H11 str. 11368]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Structures

Toxin

• AlphaFold DB: A0A0D6ZRD3

Antitoxin