Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | TMCS/- |
| Location | 1679270..1679849 | Replicon | chromosome |
| Accession | NZ_CP096532 | ||
| Organism | Staphylococcus aureus strain RIVM_M083782 | ||
Toxin (Protein)
| Gene name | MW1434 | Uniprot ID | A0A4P7P609 |
| Locus tag | M1F48_RS08275 | Protein ID | WP_001025401.1 |
| Coordinates | 1679604..1679849 (-) | Length | 82 a.a. |
Antitoxin (RNA)
| Gene name | MW1433 | ||
| Locus tag | - | ||
| Coordinates | 1679270..1679635 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M1F48_RS08235 (M1F48_08210) | 1676015..1676569 | - | 555 | Protein_1618 | DUF2815 family protein | - |
| M1F48_RS08240 (M1F48_08215) | 1676596..1677762 | - | 1167 | WP_031794951.1 | DUF2800 domain-containing protein | - |
| M1F48_RS08245 (M1F48_08220) | 1677759..1678121 | - | 363 | WP_000985976.1 | hypothetical protein | - |
| M1F48_RS08250 (M1F48_08225) | 1678136..1678459 | - | 324 | WP_000174994.1 | hypothetical protein | - |
| M1F48_RS08255 (M1F48_08230) | 1678538..1678699 | - | 162 | WP_001285948.1 | DUF1270 domain-containing protein | - |
| M1F48_RS08260 (M1F48_08235) | 1678712..1678975 | - | 264 | WP_001124198.1 | helix-turn-helix domain-containing protein | - |
| M1F48_RS08265 (M1F48_08240) | 1679000..1679215 | - | 216 | WP_001036302.1 | hypothetical protein | - |
| M1F48_RS08270 (M1F48_08245) | 1679270..1679635 | + | 366 | WP_001128433.1 | hypothetical protein | Antitoxin |
| M1F48_RS08275 (M1F48_08250) | 1679604..1679849 | - | 246 | WP_001025401.1 | DUF2829 domain-containing protein | Toxin |
| M1F48_RS08280 (M1F48_08255) | 1679905..1680114 | + | 210 | WP_000642492.1 | hypothetical protein | - |
| M1F48_RS08285 (M1F48_08260) | 1680104..1680247 | - | 144 | WP_000939498.1 | hypothetical protein | - |
| M1F48_RS08290 (M1F48_08265) | 1680318..1680530 | + | 213 | WP_000362644.1 | hypothetical protein | - |
| M1F48_RS08295 (M1F48_08270) | 1680571..1680720 | - | 150 | WP_000771849.1 | hypothetical protein | - |
| M1F48_RS08300 (M1F48_08275) | 1680760..1680984 | - | 225 | WP_000187184.1 | hypothetical protein | - |
| M1F48_RS08305 (M1F48_08280) | 1680985..1681764 | - | 780 | WP_021285981.1 | phage antirepressor | - |
| M1F48_RS08310 (M1F48_08285) | 1681790..1682017 | - | 228 | WP_001030311.1 | hypothetical protein | - |
| M1F48_RS08315 (M1F48_08290) | 1682189..1682803 | + | 615 | WP_000801423.1 | XRE family transcriptional regulator | - |
| M1F48_RS08320 (M1F48_08295) | 1682819..1683739 | + | 921 | WP_000348133.1 | exonuclease domain-containing protein | - |
| M1F48_RS08325 (M1F48_08300) | 1683965..1684111 | + | 147 | WP_074370993.1 | hypothetical protein | - |
| M1F48_RS08330 (M1F48_08305) | 1684108..1684722 | - | 615 | WP_000191466.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1635754..1703684 | 67930 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 82 a.a. Molecular weight: 9468.72 Da Isoelectric Point: 5.7783
>T243116 WP_001025401.1 NZ_CP096532:c1679849-1679604 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F
Download Length: 246 bp
>T243116 NZ_OW969912:315740-316108 [Klebsiella variicola]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGACCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCACCTGCTGGCGATTTCTCGCGGCCATATTTTCAATGATGGAAATAAGCGTACGGCACTGTTT
ATTACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAACCCGGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCGGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGCGGATGA
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGACCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCACCTGCTGGCGATTTCTCGCGGCCATATTTTCAATGATGGAAATAAGCGTACGGCACTGTTT
ATTACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAACCCGGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCGGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGCGGATGA
Antitoxin
Download Length: 366 bp
>AT243116 NZ_CP096532:1679270-1679635 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
