Detailed information of TA system TA243109

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2538440..2538624
• Replicon: chromosome
• Accession: NZ_CP096530
• Organism: Staphylococcus aureus strain RIVM_M084526

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: M1F49_RS12755
• Protein ID: WP_000482647.1
• Coordinates: 2538517..2538624 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2538440..2538500 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1F49_RS12740 (M1F49_12735)	2533894..2534061	-	168	WP_001798790.1	hypothetical protein	-
M1F49_RS12745 (M1F49_12740)	2534292..2536025	-	1734	WP_000486511.1	ABC transporter ATP-binding protein	-
M1F49_RS12750 (M1F49_12745)	2536050..2537813	-	1764	WP_267417055.1	ABC transporter ATP-binding protein	-
-	2538440..2538500	+	61	-	-	Antitoxin
M1F49_RS12755 (M1F49_12750)	2538517..2538624	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
M1F49_RS12760 (M1F49_12755)	2538758..2539144	-	387	WP_000779355.1	flippase GtxA	-
M1F49_RS12765 (M1F49_12760)	2539411..2540553	+	1143	WP_001176859.1	glycerate kinase	-
M1F49_RS12770 (M1F49_12765)	2540613..2541272	+	660	WP_000831300.1	hypothetical protein	-
M1F49_RS12775 (M1F49_12770)	2541460..2542671	+	1212	WP_001191974.1	multidrug effflux MFS transporter	-
M1F49_RS12780 (M1F49_12775)	2542794..2543267	-	474	WP_000456489.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T243109 WP_000482647.1 NZ_CP096530:c2538624-2538517 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T243109 NZ_OW969904:c4758781-4758422 [Citrobacter freundii]
ATGACGAAACCACTTTACTGGGTTGGGCAGGCCAGAAAAGACTTGCTTGCAATGCCAGAACACGTTCGGGATACGTTTGG
GTTTGCTTTTTGGCTTGCGCAGCAGGGTAAACAGCATTCACAGACTAAACCATTAAAAGGATTTGGTGGAGCAGGGGTTC
TGGAGGTCGTTGAGGATTACCACGGTAGCGCCTGGCGGGCGGTTTACACCATCCAGTTGAAAAATGCGGTTTATGTTCTC
CATGTTTTTCAGAAGAAATCCGTTTCCGGGAAGGCAACCCCGAAACCTGAAATTGACCTGATTTATCAGCGGCTCAAGGC
TGCACAGCGCCATGCGCAGGAGAGTGGATATGTCATATGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT243109 NZ_CP096530:2538440-2538500 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin