Detailed information of TA system TA243108

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprG3-SprA2AS/-
• Location: 2241321..2241519
• Replicon: chromosome
• Accession: NZ_CP096530
• Organism: Staphylococcus aureus strain RIVM_M084526

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: M1F49_RS11195
• Protein ID: WP_001802298.1
• Coordinates: 2241415..2241519 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2241321..2241359 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1F49_RS11170 (M1F49_11165)	2237441..2238106	-	666	WP_001024099.1	SDR family oxidoreductase	-
M1F49_RS11175 (M1F49_11170)	2238258..2238578	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
M1F49_RS11180 (M1F49_11175)	2238580..2239560	+	981	WP_000019735.1	CDF family zinc efflux transporter CzrB	-
M1F49_RS11185 (M1F49_11180)	2239826..2240917	+	1092	WP_000495673.1	hypothetical protein	-
M1F49_RS11190 (M1F49_11185)	2241301..2241375	+	75	Protein_2164	hypothetical protein	-
-	2241321..2241359	+	39	-	-	Antitoxin
M1F49_RS11195 (M1F49_11190)	2241415..2241519	-	105	WP_001802298.1	hypothetical protein	Toxin
M1F49_RS11200 (M1F49_11195)	2242199..2242357	+	159	WP_001792784.1	hypothetical protein	-
M1F49_RS11205 (M1F49_11200)	2242793..2242885	+	93	WP_000220902.1	hypothetical protein	-
M1F49_RS11210 (M1F49_11205)	2243015..2243872	-	858	WP_000370942.1	HAD family hydrolase	-
M1F49_RS11215 (M1F49_11210)	2243940..2244722	-	783	WP_000908191.1	ABC transporter ATP-binding protein	-
M1F49_RS11220 (M1F49_11215)	2245012..2245620	-	609	WP_000101714.1	TIR domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T243108 WP_001802298.1 NZ_CP096530:c2241519-2241415 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T243108 NZ_OW969904:c4481037-4480753 [Citrobacter freundii]
ATGACTTATGAACTGGAATTCGACCCGAGAGCCTTAAAAGAGTGGCATAAACTGGGTGATACGGTGAAGGCTCAGTTTAA
GAAGAAGTTGGCCGACGTGTTGTTGAACCCCAGAATTGACTCTGCCCGTTTAAACGGTCTTCCAGATTGCTATAAAATTA
AGCTTAAATCGTCCGGCTATCGTCTGGTGTACCAGGTTCGGGATGAGGTTGTGACCGTGTTTGTTGTCGCGGTCGGCAAG
CGAGAGCATTCGGCCGTTTATCTCGATGCAAACAAACGGCTTTAG

Antitoxin

Nucleotide

• Length: 39 bp

>AT243108 NZ_CP096530:2241321-2241359 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin