Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | TMCS/- |
| Location | 630311..630890 | Replicon | chromosome |
| Accession | NZ_CP096530 | ||
| Organism | Staphylococcus aureus strain RIVM_M084526 | ||
Toxin (Protein)
| Gene name | MW1434 | Uniprot ID | A0A4P7P609 |
| Locus tag | M1F49_RS02960 | Protein ID | WP_001025401.1 |
| Coordinates | 630311..630556 (+) | Length | 82 a.a. |
Antitoxin (RNA)
| Gene name | MW1433 | ||
| Locus tag | - | ||
| Coordinates | 630525..630890 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M1F49_RS02900 (M1F49_02900) | 625622..626218 | - | 597 | WP_031796639.1 | hypothetical protein | - |
| M1F49_RS02905 (M1F49_02905) | 626275..626886 | - | 612 | WP_267417186.1 | XRE family transcriptional regulator | - |
| M1F49_RS02910 (M1F49_02910) | 627058..627285 | + | 228 | WP_001030311.1 | hypothetical protein | - |
| M1F49_RS02915 (M1F49_02915) | 627311..628090 | + | 780 | WP_021285981.1 | phage antirepressor | - |
| M1F49_RS02920 (M1F49_02920) | 628091..628315 | + | 225 | WP_031867688.1 | hypothetical protein | - |
| M1F49_RS02925 (M1F49_02925) | 628352..628795 | + | 444 | WP_000435357.1 | hypothetical protein | - |
| M1F49_RS02930 (M1F49_02930) | 628810..628959 | + | 150 | WP_000771849.1 | hypothetical protein | - |
| M1F49_RS02935 (M1F49_02935) | 629000..629212 | - | 213 | WP_000362644.1 | hypothetical protein | - |
| M1F49_RS02940 (M1F49_02940) | 629282..629479 | + | 198 | WP_001148860.1 | hypothetical protein | - |
| M1F49_RS02945 (M1F49_02945) | 629466..629846 | - | 381 | WP_267417198.1 | DUF2513 domain-containing protein | - |
| M1F49_RS02950 (M1F49_02950) | 629913..630056 | + | 144 | WP_000939498.1 | hypothetical protein | - |
| M1F49_RS02955 (M1F49_02955) | 630046..630255 | - | 210 | WP_000642492.1 | hypothetical protein | - |
| M1F49_RS02960 (M1F49_02960) | 630311..630556 | + | 246 | WP_001025401.1 | DUF2829 domain-containing protein | Toxin |
| M1F49_RS02965 (M1F49_02965) | 630525..630890 | - | 366 | WP_001128433.1 | hypothetical protein | Antitoxin |
| M1F49_RS02970 (M1F49_02970) | 630945..631160 | + | 216 | WP_001036302.1 | hypothetical protein | - |
| M1F49_RS02975 (M1F49_02975) | 631185..631448 | + | 264 | WP_031776084.1 | helix-turn-helix domain-containing protein | - |
| M1F49_RS02980 (M1F49_02980) | 631461..631619 | + | 159 | WP_267417205.1 | DUF1270 family protein | - |
| M1F49_RS02985 (M1F49_02985) | 631717..632019 | + | 303 | WP_031794901.1 | DUF2482 family protein | - |
| M1F49_RS02990 (M1F49_02990) | 632024..632284 | + | 261 | WP_267417208.1 | DUF1108 family protein | - |
| M1F49_RS02995 (M1F49_02995) | 632292..632528 | + | 237 | WP_000802315.1 | hypothetical protein | - |
| M1F49_RS03000 (M1F49_03000) | 632521..633000 | + | 480 | WP_070044634.1 | siphovirus Gp157 family protein | - |
| M1F49_RS03005 (M1F49_03005) | 633000..633638 | + | 639 | WP_021285877.1 | ERF family protein | - |
| M1F49_RS03010 (M1F49_03010) | 633638..634063 | + | 426 | WP_050960859.1 | single-stranded DNA-binding protein | - |
| M1F49_RS03015 (M1F49_03015) | 634077..634751 | + | 675 | WP_267417222.1 | putative HNHc nuclease | - |
| M1F49_RS03020 (M1F49_03020) | 634744..635499 | + | 756 | WP_267417224.1 | DnaD domain protein | - |
| M1F49_RS03025 (M1F49_03025) | 635499..635855 | + | 357 | WP_001132247.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 615408..669698 | 54290 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 82 a.a. Molecular weight: 9468.72 Da Isoelectric Point: 5.7783
>T243100 WP_001025401.1 NZ_CP096530:630311-630556 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F
Download Length: 246 bp
>T243100 NZ_OW969904:684764-685084 [Citrobacter freundii]
ATGCAAATCTCAACTGTACCGGCCACGTTGCCGGTTTCGTCACGCCTGTCTCCCGTCCAGGTGTGGCAACAACTGTTAAC
GTATCTACTGGAACACCATTACGGCCTCACACTCAACGACACGCCATTCCACAATGAGTCAGCTATTCGTGAGCACATCG
AAGCGGGAATAACGCTTGCTGATGCGTTGAATTTTCTTGTGGAACGCTATGAACTGATACGCACTGACCGCAAAGGGTTT
ACATGGCAGGAGCAGACACCGTTCCTGACCGCGACCGATATTCTCAGAGCCAGACGAGCTACCGGGTTGATGAATACGTA
A
ATGCAAATCTCAACTGTACCGGCCACGTTGCCGGTTTCGTCACGCCTGTCTCCCGTCCAGGTGTGGCAACAACTGTTAAC
GTATCTACTGGAACACCATTACGGCCTCACACTCAACGACACGCCATTCCACAATGAGTCAGCTATTCGTGAGCACATCG
AAGCGGGAATAACGCTTGCTGATGCGTTGAATTTTCTTGTGGAACGCTATGAACTGATACGCACTGACCGCAAAGGGTTT
ACATGGCAGGAGCAGACACCGTTCCTGACCGCGACCGATATTCTCAGAGCCAGACGAGCTACCGGGTTGATGAATACGTA
A
Antitoxin
Download Length: 366 bp
>AT243100 NZ_CP096530:c630890-630525 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
