243098

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2484474..2484658 Replicon chromosome
Accession NZ_CP096528
Organism Staphylococcus aureus strain RIVM_M084986

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag M1F50_RS12350 Protein ID WP_000482647.1
Coordinates 2484551..2484658 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2484474..2484534 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1F50_RS12335 (M1F50_12315) 2479928..2480095 - 168 WP_001798790.1 hypothetical protein -
M1F50_RS12340 (M1F50_12320) 2480326..2482059 - 1734 WP_000486511.1 ABC transporter ATP-binding protein -
M1F50_RS12345 (M1F50_12325) 2482084..2483847 - 1764 WP_001064818.1 ABC transporter ATP-binding protein -
- 2484474..2484534 + 61 - - Antitoxin
M1F50_RS12350 (M1F50_12330) 2484551..2484658 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
M1F50_RS12355 (M1F50_12335) 2484792..2485178 - 387 WP_000779355.1 flippase GtxA -
M1F50_RS12360 (M1F50_12340) 2485445..2486587 + 1143 WP_001176859.1 glycerate kinase -
M1F50_RS12365 (M1F50_12345) 2486647..2487306 + 660 WP_000831300.1 hypothetical protein -
M1F50_RS12370 (M1F50_12350) 2487494..2488705 + 1212 WP_001191974.1 multidrug effflux MFS transporter -
M1F50_RS12375 (M1F50_12355) 2488828..2489301 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T243098 WP_000482647.1 NZ_CP096528:c2484658-2484551 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T243098 NZ_OW969904:246459-246734 [Citrobacter freundii]
ATGAAGGAAAAAGTGTTGTCTTTACGCAAAAAGCAAAAGAACACGCTGGATCAGCTTTTTAAAGCACCGACGCCGCAGGG
AATCAAGTGGTCGGAAATTGAGTCACTGATCAAGGCGTTAGGTGGCGAAATCAAAGAAGGACGAGGCTCGCGATGTAAAT
TTCTTTTAAATAAGAGCATTGCGAGTTTTCATAGACCACATCCTTCTCCGGATACAGATAAAGGCGCGGTCGAAAACGTA
CGTGACTGGTTAACAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 61 bp

>AT243098 NZ_CP096528:2484474-2484534 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References