Detailed information of TA system TA243097

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprG3-SprA2AS/-
• Location: 2188700..2188898
• Replicon: chromosome
• Accession: NZ_CP096528
• Organism: Staphylococcus aureus strain RIVM_M084986

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: M1F50_RS10800
• Protein ID: WP_001802298.1
• Coordinates: 2188794..2188898 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2188700..2188738 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1F50_RS10775 (M1F50_10755)	2184820..2185485	-	666	WP_001024099.1	SDR family oxidoreductase	-
M1F50_RS10780 (M1F50_10760)	2185637..2185957	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
M1F50_RS10785 (M1F50_10765)	2185959..2186939	+	981	WP_000019735.1	CDF family zinc efflux transporter CzrB	-
M1F50_RS10790 (M1F50_10770)	2187205..2188296	+	1092	WP_000495673.1	hypothetical protein	-
M1F50_RS10795 (M1F50_10775)	2188680..2188754	+	75	Protein_2084	hypothetical protein	-
-	2188700..2188738	+	39	-	-	Antitoxin
M1F50_RS10800 (M1F50_10780)	2188794..2188898	-	105	WP_001802298.1	hypothetical protein	Toxin
M1F50_RS10805 (M1F50_10785)	2189578..2189736	+	159	WP_001792784.1	hypothetical protein	-
M1F50_RS10810 (M1F50_10790)	2190172..2190264	+	93	WP_000220902.1	hypothetical protein	-
M1F50_RS10815 (M1F50_10795)	2190394..2191251	-	858	WP_000370942.1	HAD family hydrolase	-
M1F50_RS10820 (M1F50_10800)	2191319..2192101	-	783	WP_000908191.1	ABC transporter ATP-binding protein	-
M1F50_RS10825 (M1F50_10805)	2192391..2192999	-	609	WP_000101714.1	TIR domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T243097 WP_001802298.1 NZ_CP096528:c2188898-2188794 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T243097 NZ_OW969904:40128-40490 [Citrobacter freundii]
ATGTGGGAAGTGGAAACAACGGATGCTTTCGATAAATGGTTTGACGTACAGACCGAAGCGCTCAAGGAAGATATGCTCGC
AGCAATGATGATTTTATCCGAGTATGGTCCTCAGTTAGGCAGGCCGTTTGCTGATACGGTAAATGCTTCTGCTTTTTCAA
ATATGAAAGAGTTGCGAGTACAGCATCAGGGTAGTCCGATTCGGGCGTTCTTCGCGTTTGATCCTTCTCGCCATGGCATC
GTGCTATGCGCTGGAGATAAAACAGGGTTAAACGAAAAGAAATTCTATAAAGAGATGATCAGGCTTGCGGATGCTGAGTA
CCGAAATCACCTAATAAGTAAGGAAAATTATGGCTACCCTTAA

Antitoxin

Nucleotide

• Length: 39 bp

>AT243097 NZ_CP096528:2188700-2188738 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin