Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | TMCS/- |
| Location | 368251..368830 | Replicon | chromosome |
| Accession | NZ_CP096528 | ||
| Organism | Staphylococcus aureus strain RIVM_M084986 | ||
Toxin (Protein)
| Gene name | MW1434 | Uniprot ID | A0A4P7P609 |
| Locus tag | M1F50_RS01675 | Protein ID | WP_001025401.1 |
| Coordinates | 368251..368496 (+) | Length | 82 a.a. |
Antitoxin (RNA)
| Gene name | MW1433 | ||
| Locus tag | - | ||
| Coordinates | 368465..368830 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| M1F50_RS01625 (M1F50_01615) | 363826..363972 | - | 147 | WP_001013104.1 | hypothetical protein | - |
| M1F50_RS01630 (M1F50_01620) | 364202..364798 | - | 597 | WP_031796639.1 | hypothetical protein | - |
| M1F50_RS01635 (M1F50_01625) | 364855..365484 | - | 630 | WP_029549401.1 | XRE family transcriptional regulator | - |
| M1F50_RS01640 (M1F50_01630) | 365638..365865 | + | 228 | WP_015978369.1 | helix-turn-helix transcriptional regulator | - |
| M1F50_RS01645 (M1F50_01635) | 365888..366664 | + | 777 | WP_031796638.1 | Rha family transcriptional regulator | - |
| M1F50_RS01650 (M1F50_01640) | 366690..367133 | + | 444 | WP_031775158.1 | hypothetical protein | - |
| M1F50_RS01655 (M1F50_01645) | 367148..367297 | + | 150 | WP_000771849.1 | hypothetical protein | - |
| M1F50_RS01660 (M1F50_01650) | 367338..367550 | - | 213 | WP_000362644.1 | hypothetical protein | - |
| M1F50_RS01665 (M1F50_01655) | 367620..367817 | + | 198 | WP_001148860.1 | hypothetical protein | - |
| M1F50_RS01670 (M1F50_01660) | 367804..368184 | - | 381 | WP_000773059.1 | DUF2513 domain-containing protein | - |
| M1F50_RS01675 (M1F50_01665) | 368251..368496 | + | 246 | WP_001025401.1 | DUF2829 domain-containing protein | Toxin |
| M1F50_RS01680 (M1F50_01670) | 368465..368830 | - | 366 | WP_001128433.1 | hypothetical protein | Antitoxin |
| M1F50_RS01685 (M1F50_01675) | 368885..369100 | + | 216 | WP_001097552.1 | hypothetical protein | - |
| M1F50_RS01690 (M1F50_01680) | 369125..369388 | + | 264 | WP_001124160.1 | helix-turn-helix domain-containing protein | - |
| M1F50_RS01695 (M1F50_01685) | 369401..369562 | + | 162 | WP_001285959.1 | DUF1270 domain-containing protein | - |
| M1F50_RS01700 (M1F50_01690) | 369654..369914 | + | 261 | WP_000291089.1 | DUF1108 family protein | - |
| M1F50_RS01705 (M1F50_01695) | 369924..370145 | + | 222 | WP_000815402.1 | DUF2483 family protein | - |
| M1F50_RS01710 (M1F50_01700) | 370138..370761 | + | 624 | WP_000139720.1 | DUF1071 domain-containing protein | - |
| M1F50_RS01715 (M1F50_01705) | 370761..371186 | + | 426 | WP_000934384.1 | single-stranded DNA-binding protein | - |
| M1F50_RS01720 (M1F50_01710) | 371197..371748 | + | 552 | WP_001004506.1 | NUMOD4 domain-containing protein | - |
| M1F50_RS01725 (M1F50_01715) | 371749..372423 | + | 675 | WP_031913921.1 | putative HNHc nuclease | - |
| M1F50_RS01730 (M1F50_01720) | 372416..373171 | + | 756 | WP_001037657.1 | DnaD domain protein | - |
| M1F50_RS01735 (M1F50_01725) | 373171..373527 | + | 357 | WP_031913922.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 361885..407515 | 45630 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 82 a.a. Molecular weight: 9468.72 Da Isoelectric Point: 5.7783
>T243090 WP_001025401.1 NZ_CP096528:368251-368496 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F
Download Length: 246 bp
>T243090 NZ_OW969781:c61177-60869 [Klebsiella oxytoca]
ATGCAGTATTACGTTTATAAGAATACAGGTCGAATTGCTGCGTATCCTTACCTCCTTGATGTACAGAGTGACATTATCGG
CGAGCGCAATACTCGGGTTGTGATTCCACTGTTTCCACTGAAAAACTATAAAGGTCCACGCGCCGATCGTTTAACACCGC
TTGTCACCGTAGAAGGGGAAGAATACGTCGTGATGACTCACGAACTCGCCAGCATCCCACATCGTGTTCTGGGTGAAGAG
GTTTGTAATCTGAATCACCAGCGCGAAGTCGTTAAAGCTTCAATGGATTTTCTTTTCGACGGGATCTAA
ATGCAGTATTACGTTTATAAGAATACAGGTCGAATTGCTGCGTATCCTTACCTCCTTGATGTACAGAGTGACATTATCGG
CGAGCGCAATACTCGGGTTGTGATTCCACTGTTTCCACTGAAAAACTATAAAGGTCCACGCGCCGATCGTTTAACACCGC
TTGTCACCGTAGAAGGGGAAGAATACGTCGTGATGACTCACGAACTCGCCAGCATCCCACATCGTGTTCTGGGTGAAGAG
GTTTGTAATCTGAATCACCAGCGCGAAGTCGTTAAAGCTTCAATGGATTTTCTTTTCGACGGGATCTAA
Antitoxin
Download Length: 366 bp
>AT243090 NZ_CP096528:c368830-368465 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
