Detailed information of TA system TA243088

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2503141..2503325
• Replicon: chromosome
• Accession: NZ_CP096526
• Organism: Staphylococcus aureus strain RIVM_M087195

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: M1F51_RS12385
• Protein ID: WP_000482647.1
• Coordinates: 2503218..2503325 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2503141..2503201 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M1F51_RS12370 (M1F51_12345)	2498595..2498762	-	168	WP_001798790.1	hypothetical protein	-
M1F51_RS12375 (M1F51_12350)	2498993..2500726	-	1734	WP_000486511.1	ABC transporter ATP-binding protein	-
M1F51_RS12380 (M1F51_12355)	2500751..2502514	-	1764	WP_001064818.1	ABC transporter ATP-binding protein	-
-	2503141..2503201	+	61	-	-	Antitoxin
M1F51_RS12385 (M1F51_12360)	2503218..2503325	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
M1F51_RS12390 (M1F51_12365)	2503459..2503845	-	387	WP_000779355.1	flippase GtxA	-
M1F51_RS12395 (M1F51_12370)	2504112..2505254	+	1143	WP_001176859.1	glycerate kinase	-
M1F51_RS12400 (M1F51_12375)	2505314..2505973	+	660	WP_000831300.1	hypothetical protein	-
M1F51_RS12405 (M1F51_12380)	2506161..2507372	+	1212	WP_001191974.1	multidrug effflux MFS transporter	-
M1F51_RS12410 (M1F51_12385)	2507495..2507968	-	474	WP_000456489.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T243088 WP_000482647.1 NZ_CP096526:c2503325-2503218 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T243088 NZ_OW969711:c4416580-4416272 [Citrobacter koseri]
ATGCACGTCATTTCAAAAGAACCTTTTGAGGAAGCGGCAAAGCGATATCCCAACGATTCGTTAGCCATACGGGCGCTGTA
CCGCTTAATGCGTGAAACTGACTTCTCTTCTCCGACTGAGATGAGAACTCTGATACCGAGCCTGGACAATTTTAAGTACC
GGAACAAATGGTGGGTTCTGGATGTGGGAGGCAACAACTTGAGGGTTATCGCCTACATCAATTTTGTGAACAAACGCTTC
TATGTGAAGCACATCAGCACCCACGCTGAATATGACAAGTTGACCCGCTATTACAGGGAGAACAAATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT243088 NZ_CP096526:2503141-2503201 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin